Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itpr3provided by RGD
Official Full Name: inositol 1,4,5-trisphosphate receptor, type 3provided by RGD
Primary source: RGD:2934
See related: EnsemblRapid:ENSRNOG00000052795 AllianceGenome:RGD:2934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IP3R3; IP3R-3; IP3R3X
Summary: Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including apical plasma membrane; brush border; and nuclear outer membrane. Is active in endoplasmic reticulum membrane and presynapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 52.8), Spleen (RPKM 47.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (5138553..5204189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (5136968..5202339)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5645894..5711702)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An age-related decline in IP3R3 expression and NPY signaling underlie age-related homeostatic changes and olfactory dysfunction.
Title: Effect of IP3R3 and NPY on age-related declines in olfactory stem cell proliferation.
It regulates calcium transients in neonatal rat ventricular myocytes.(37-46)
Title: Role of inositol-1,4,5-trisphosphate receptor in the regulation of calcium transients in neonatal rat ventricular myocytes.
Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3R3.
Title: Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.
Inositol 1,4,5-trisphosphate and IP3 receptors act as inhibitors of autophagic processes in cardiomyocytes.
Title: Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P(3) and IP(3)-receptors.
A phosphomimetic mutation at T-930 of the rat Ins(1,4,5)P 3 receptor results in decreased Ins(1,4,5)P 3-dependent Ca ( 2+) release and lowers the Ins(1,4,5)P 3 binding affinity of the receptor.
Title: Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃.
Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine signaling pathway that involves CFTR, apical release of ATP, stimulation of apical nucleotide receptors, and then activation of apical, type III InsP3Rs.
Title: Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.
After apoptosis induction calcium permeability of the nuclear calcium store vesicles increases via IP(3) receptor translocation to nucleus.
Title: Apoptosis induced clustering of IP(3)R1 in nuclei of non-differentiated PC12 cells.
Sulfhydryl redox modification can regulate various aspects of intracellular Ca2+ signaling, including quantal Ca2+ release, by tuning ligand sensitivities of InsP3R channels.
Title: Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels.
findings show that repeated exposure to amphetamine causes sensitization of IP3 receptors in ventral tegmental area dopamine neurons, resulting in an enhancement of mGluR-dependent NMDA receptor LTP
Title: IP3 receptor sensitization during in vivo amphetamine experience enhances NMDA receptor plasticity in dopamine neurons of the ventral tegmental area.
findings show that changes in cellular oxidation/reduction balance during hypoxia increase cytosolic NAD(P)H, and that this triggers the release of Ca2+ from the endoplasmic reticulum via activation of IP3 receptors
Title: Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC275467P4 (e-PCR)
- UniSTS:272385

RH129560 (e-PCR)
- UniSTS:212862

RH129567 (e-PCR)
- UniSTS:212869

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol 1,3,4,5 tetrakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables inositol hexakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sweet taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of umami taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of umami taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; inositol 1,4,5-trisphosphate receptor type 3

Names: IP3 receptor; IP3R 3; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; type 3 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013138.2 → NP_037270.2 inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q63269

UniProtKB/TrEMBL

C7E1V1

Related

ENSRNOP00000075066.3, ENSRNOT00000090925.4

Conserved Domains (5) summary

pfam00520
Location:2235 → 2527

Ion_trans; Ion transport protein

pfam01365
Location:473 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:234 → 432

MIR; MIR domain

pfam08454
Location:1864 → 1973

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:3 → 230

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor