Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gucy1b2provided by RGD
Official Full Name: guanylate cyclase 1 soluble subunit beta 2provided by RGD
Primary source: RGD:2770
See related: EnsemblRapid:ENSRNOG00000009440 AllianceGenome:RGD:2770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SGC; Gucy1b2a; Gucy1b2b
Summary: Enables nitric oxide binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be located in cytosol. Predicted to be part of guanylate cyclase complex, soluble. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 119.4), Liver (RPKM 107.1) and 1 other tissue See more
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Genomic context

Location:: 15p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (40774907..40845463, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (36589501..36669441, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (45479662..45550285, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data support our hypothesis and provide anatomical support for the suggestion that nitroxidergic activation of the NTS involves sGC.
Title: Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii.
Expression of the beta 2 subunit of soluble guanylyl cyclase is switched on at a time when the urinary concentrating capacity develops, between postnatal days 16 to 22, increasing strongly in intensity in adult animals.
Title: The beta 2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney.
Results identify and characterize the minimum functional ligand-binding heme domain derived from soluble guanylate cyclase.
Title: Characterization of functional heme domains from soluble guanylate cyclase.
for the function of sGC in vivo, where there is evidence for two nitric oxide-regulated activity states
Title: Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.

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General gene information

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Markers

Gucy1b2 (e-PCR), detects polymorphism
- UniSTS:525450

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylate cyclase soluble subunit beta-2

Names: GCS-beta-2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); guanylate cyclase 1, soluble, beta 2; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b

NP_001257640.1

EC 4.6.1.2

NP_036902.2

EC 4.6.1.2

XP_008768963.3

EC 4.6.1.2

XP_063130063.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270711.1 → NP_001257640.1 guanylate cyclase soluble subunit beta-2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AB109451, AY004153, M57507

UniProtKB/TrEMBL

A0A0G2QC51, Q91XJ7

Related

ENSRNOP00000012948.4, ENSRNOT00000012948.7

Conserved Domains (4) summary

smart00044
Location:432 → 622

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:459 → 642

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:2 → 163

HNOB; Haem-NO-binding

pfam07701
Location:267 → 453

HNOBA; Heme NO binding associated
NM_012770.2 → NP_036902.2 guanylate cyclase soluble subunit beta-2 isoform 2

See identical proteins and their annotated locations for NP_036902.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB109451, M57507

UniProtKB/TrEMBL

F1M7R3, Q80WY0

Conserved Domains (4) summary

smart00044
Location:397 → 587

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:424 → 607

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:1 → 128

HNOB; Haem-NO-binding

pfam07701
Location:232 → 418

HNOBA; Heme NO binding associated