Clps colipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clpsprovided by RGD
Official Full Name: colipaseprovided by RGD
Primary source: RGD:2363
See related: EnsemblRapid:ENSRNOG00000000510 AllianceGenome:RGD:2363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COLQ
Summary: Enables enzyme activator activity. Involved in positive regulation of catalytic activity; post-embryonic development; and response to food. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CLPS (colipase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1512.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6622234..6624414, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6620529..6622709, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5803447..5806107, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables lipase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to food	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: colipase

Names: colipase, pancreatic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013139.2 → NP_037271.2 colipase precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P17084

UniProtKB/TrEMBL

F1LNA9

Related

ENSRNOP00000000611.3, ENSRNOT00000000611.6

Conserved Domains (1) summary

smart00023
Location:18 → 112

COLIPASE; Colipase