Sdha succinate dehydrogenase complex flavoprotein subunit A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sdhaprovided by RGD
Official Full Name: succinate dehydrogenase complex flavoprotein subunit Aprovided by RGD
Primary source: RGD:621557
See related: EnsemblRapid:ENSRNOG00000013331 AllianceGenome:RGD:621557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables succinate dehydrogenase (quinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 3217.6), Muscle (RPKM 2121.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (30764553..30789523)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (28935965..28960936)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (31545631..31570601)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Molecular and biochemical studies of succinate dehydrogenase in rat liver under conditions of alloxan diabetes].", trans "Molekuliarnye i biokhimicheskie issledovaniia suktsinatdegidrogenazy v pecheni krys v usloviiakh alloksanovogo diabeta.
Title: [Molecular and biochemical studies of succinate dehydrogenase in rat liver under conditions of alloxan diabetes].
Data suggest activation/acetylation of Sdha in skeletal muscle can be regulated by diet; maternal low-protein leads to inactivation of Sdha; postnatal high-fat leads to further inactivation of Sdha; this increases susceptibility to type 2 diabetes.
Title: Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low-protein diet.
Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine.
Title: Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
up-regulated by 24 % in peritoneal adhesions
Title: Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa.
Data show that MCT-KD intake partially recovers age-related decrease of SDH activity and increases the myocardial area occupied by metabolically active mitochondria.
Title: A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes.
SDHa flavoprotein transcriptional regulation by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells
Title: Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to succinate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables succinate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
contributes_to succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	NAS Non-traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	ISS Inferred from Sequence or Structural Similarity more info
involved_in succinate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in succinate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in succinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in succinate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Names: flavoprotein subunit of complex II; fp; malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

NP_569112.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130428.1 → NP_569112.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_569112.1

Status: PROVISIONAL

Source sequence(s)

AB072907

UniProtKB/Swiss-Prot

Q920L2

UniProtKB/TrEMBL

A0A8L2Q9A7, A6JUU5

Related

ENSRNOP00000018336.5, ENSRNOT00000018336.6

Conserved Domains (3) summary

PTZ00139
Location:44 → 656

PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

pfam02910
Location:507 → 656

Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

cl21454
Location:77 → 463

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins