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    Mcm3ap minichromosome maintenance complex component 3 associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294339, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mcm3approvided by RGD
    Official Full Name
    minichromosome maintenance complex component 3 associated proteinprovided by RGD
    Primary source
    RGD:1306834
    See related
    EnsemblRapid:ENSRNOG00000001272 AllianceGenome:RGD:1306834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and histone binding activity. Predicted to be involved in nucleosome organization; poly(A)+ mRNA export from nucleus; and somatic hypermutation of immunoglobulin genes. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Predicted to be active in cytoplasm and nucleus. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 166.1), Lung (RPKM 117.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm3ap in Genome Data Viewer
    Location:
    20p12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12127060..12164651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12127570..12165165, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (12879304..12917069, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483885 Neighboring gene spermatogenesis and centriole associated 1-like Neighboring gene lanosterol synthase Neighboring gene similar to human chromosome 21 open reading frame 58 Neighboring gene ybeY metalloendoribonuclease Neighboring gene pericentrin Neighboring gene uncharacterized LOC134483886

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2. Chen K, et al. Cell Cycle, 2022 Apr. PMID 35113004, Free PMC Article
    2. A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Kuwahara K, et al. Blood, 2000 Apr 1. PMID 10733502
    3. The human TREX-2 complex is stably associated with the nuclear pore basket. Umlauf D, et al. J Cell Sci, 2013 Jun 15. PMID 23591820
    4. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Singh SK, et al. Nat Commun, 2013. PMID 23652018, Free PMC Article
    5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2.
      Title: Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    germinal-center associated nuclear protein
    Names
    80 kDa MCM3-associated protein
    minichromosome maintenance deficient 3 associated protein
    XP_006256356.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434618.1 → NP_001421547.1  germinal-center associated nuclear protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    2. NM_001434619.1 → NP_001421548.1  germinal-center associated nuclear protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12127060..12164651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256294.5 → XP_006256356.1  germinal-center associated nuclear protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV99, A6JKD0
      Related
      ENSRNOP00000069402.1, ENSRNOT00000081445.3
      Conserved Domains (6) summary
      cd12443
      Location:433 → 501
      RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
      pfam03399
      Location:684 → 908
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam13634
      Location:2 → 95
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16766
      Location:1162 → 1231
      CID_GANP; Binding region of GANP to ENY2
      pfam16768
      Location:2 → 289
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
      pfam16769
      Location:1259 → 1971
      MCM3AP_GANP; MCM3AP domain of GANP

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106382.1: Suppressed sequence

      Description
      NM_001106382.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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