Tnfrsf21 TNF receptor superfamily member 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfrsf21provided by RGD
Official Full Name: TNF receptor superfamily member 21provided by RGD
Primary source: RGD:1307308
See related: EnsemblRapid:ENSRNOG00000011517 AllianceGenome:RGD:1307308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in axonal fasciculation. Predicted to be located in axon. Predicted to be active in plasma membrane. Orthologous to human TNFRSF21 (TNF receptor superfamily member 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 305.3), Muscle (RPKM 95.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (25376400..25451323, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17879156..17954085, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20546159..20621051, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrated that miR-210 decreased inflammation in articular cavity in OA rats by targeting DR6 and inhibiting NF-kappaB signaling pathway.
Title: MiR-210 inhibits NF-κB signaling pathway by targeting DR6 in osteoarthritis.

Submit: New GeneRIF Correction

General gene information

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Markers

AW535277 (e-PCR)
- UniSTS:247210

RH130936 (e-PCR)
- UniSTS:214220

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-13 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-5 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 21

Names: death receptor 6; tumor necrosis factor receptor superfamily, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108207.1 → NP_001101677.1 tumor necrosis factor receptor superfamily member 21 precursor

See identical proteins and their annotated locations for NP_001101677.1

Status: PROVISIONAL

Source sequence(s)

CH473987

UniProtKB/Swiss-Prot

D3ZF92

Related

ENSRNOP00000015918.5, ENSRNOT00000015918.7

Conserved Domains (3) summary

cd08778
Location:414 → 497

Death_TNFRSF21; Death domain of tumor necrosis factor receptor superfamily member 21

cd10583
Location:53 → 211

TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)

cl14633
Location:594 → 655

DD; Death Domain Superfamily of protein-protein interaction domains