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    Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arih2provided by RGD
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1305839
    See related
    EnsemblRapid:ENSRNOG00000031827 AllianceGenome:RGD:1305839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ARI2; TRIAD1
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; positive regulation of protein targeting to mitochondrion; and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 181.6), Heart (RPKM 148.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arih2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118175267..118234425, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109296738..109355909, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117387004..117446085, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene uncharacterized LOC120094262 Neighboring gene solute carrier family 25 member 20 Neighboring gene uncharacterized LOC134480235 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit alpha Neighboring gene uncharacterized LOC134480236

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin. Wu C, et al. J Biol Chem, 2022 Oct. PMID 36055408, Free PMC Article
    2. E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury. Wu C, et al. Somatosens Mot Res, 2022 Mar. PMID 34641746
    3. The expression of TRIAD1 and DISC1 after traumatic brain injury and its influence on NSCs. Jiang R, et al. Stem Cell Res Ther, 2018 Nov 8. PMID 30409224, Free PMC Article
    4. Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury. Wu C, et al. J Cell Biochem, 2019 Apr. PMID 30320922
    5. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. Marteijn JA, et al. Blood, 2005 Dec 15. PMID 16118314

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin.
      Title: Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin.
    2. E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury.
      Title: E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury.
    3. Our data delineate a novel interaction between Triad1 and EHD1 that may contribute to the regulation of neurite outgrowth for neurons after the spinal cord injury.
      Title: Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury.
    4. the expression of TRIAD1 and DISC1 change after traumatic brain injury and that their interaction may affect the proliferation and differentiation of neural stem cells.
      Title: The expression of TRIAD1 and DISC1 after traumatic brain injury and its influence on NSCs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    ariadne homolog 2
    NP_001012275.1
    XP_006243847.1
    XP_006243849.1
    XP_008764759.1
    XP_038937528.1
    XP_063121700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012275.2 → NP_001012275.1  E3 ubiquitin-protein ligase ARIH2

      See identical proteins and their annotated locations for NP_001012275.1

      Status: VALIDATED

      Source sequence(s)
      BF284740, CB702620, CV114328, CV126331, JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A0Y1, A6I373, D3ZJB8
      Related
      ENSRNOP00000050012.3, ENSRNOT00000042577.6
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118175267..118234425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766537.4 → XP_008764759.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      See identical proteins and their annotated locations for XP_008764759.1

      UniProtKB/TrEMBL
      A0A8I6A0Y1, A6I373, D3ZJB8
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    2. XM_006243785.5 → XP_006243847.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      See identical proteins and their annotated locations for XP_006243847.1

      UniProtKB/TrEMBL
      A0A8I6A0Y1, A6I373, D3ZJB8
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    3. XM_039081600.2 → XP_038937528.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0Y1, A6I373, D3ZJB8
      Conserved Domains (3) summary
      smart00647
      Location:207 → 269
      IBR; In Between Ring fingers
      cd16773
      Location:136 → 189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297 → 329
      IBR; IBR domain, a half RING-finger domain

    4. XM_006243787.4 → XP_006243849.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0Y1
      Conserved Domains (2) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    5. XM_063265630.1 → XP_063121700.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0Y1
    Nucleotide Protein Strain
    Heading Accession and Version

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