Fkbp1a FKBP prolyl isomerase 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fkbp1aprovided by RGD
Official Full Name: FKBP prolyl isomerase 1Aprovided by RGD
Primary source: RGD:2617
See related: AllianceGenome:RGD:2617
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fkbp2; FKBP12
Summary: Enables several functions, including FK506 binding activity; Hsp70 protein binding activity; and type I transforming growth factor beta receptor binding activity. Involved in response to iron ion. Located in axon terminus. Biomarker of Parkinsonism. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 898.7), Lung (RPKM 748.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160500748..160520492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140040359..140060107)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147042944..147062725)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKBP12 can endogenously regulate calcineurin activity with therapeutic implications for the treatment of Parkinson's Disease.
Title: FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.
The effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels, were investigated.
Title: FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
FKBP12 regulates H-Ras trafficking by promoting depalmitoylation through cis-trans isomerization of a peptidyl-prolyl bond in proximity to the palmitoylated cysteines.
Title: FKBP12 binds to acylated H-ras and promotes depalmitoylation.
Increased susceptibility to ventricular fibrillation in l-thyroxin-induced cardiomyopathy is related to increase in diastolic Ca(2+) levels, resulting from downregulated FKBP12.6 and upregulated endothelin system
Title: Downregulated FKBP12.6 expression and upregulated endothelin signaling contribute to elevated diastolic calcium and arrhythmogenesis in rat cardiomyopathy produced by l-thyroxin.
FKBP12 is predominantly present during early neointima formation, while mature neointimal atheromas show a relatively low expression without confinement to luminal areas.
Title: Neointimal expression of rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics.
the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca(2+) release and stress-induced ventricular arrhythmias
Title: Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias.
These data strongly suggests that FKBP-12 is altered in an experimental model of PD.
Title: Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.
Data show that K201 abolished spontaneous calcium release in cardiac myocytes, and that treating ventricular myocytes with FK506 to dissociate FKBP12.6 from ryanodine receptor RyR2 did not affect the suppression of spontaneous Ca2+ release by K201.
Title: K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association.
localized to penile innervation in the rat and becomes upregulated following cavernous nerve crush injury
Title: FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FK506 binding	IDA Inferred from Direct Assay more info	PubMed
enables FK506 binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables activin receptor binding	ISO Inferred from Sequence Orthology more info
enables channel regulator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein peptidyl-prolyl isomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of ryanodine receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP1A

Names: 12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1a; FK506 binding protein 2 (13 kDa); FK506-binding protein 1 (12kD); FK506-binding protein 1A; FKBP-12; FKBP-1A; PPIase FKBP1A; immunophilin FKBP12; rotamase

NP_037234.2

EC 5.2.1.8

XP_038960313.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013102.3 → NP_037234.2 peptidyl-prolyl cis-trans isomerase FKBP1A

See identical proteins and their annotated locations for NP_037234.2

Status: PROVISIONAL

Source sequence(s)

BC070519

UniProtKB/Swiss-Prot

A0JN04, P97533, Q62658

UniProtKB/TrEMBL

A0A8L2UIH3, A6KHI5

Conserved Domains (1) summary

COG0545
Location:2 → 106

FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

160500748..160520492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104385.2 → XP_038960313.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform X1

UniProtKB/TrEMBL

A6KHI7

Conserved Domains (1) summary

pfam00254
Location:1 → 76

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase