Anxa3 annexin A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anxa3provided by RGD
Official Full Name: annexin A3provided by RGD
Primary source: RGD:2119
See related: EnsemblRapid:ENSRNOG00000002045 AllianceGenome:RGD:2119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LC3; Anx3; LRRGT00047
Summary: Enables calcium-dependent phospholipid binding activity and phospholipase A2 inhibitor activity. Involved in several processes, including animal organ regeneration; hippocampus development; and response to glucocorticoid. Located in axon; dendrite; and neuronal cell body. Biomarker of glaucoma. Orthologous to human ANXA3 (annexin A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 447.7), Lung (RPKM 306.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (13031675..13085678, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (12727708..12781717, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (14371921..14426503, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting with LC3.
Title: NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting with LC3.
Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells.
Title: Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells.
Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats.
Title: Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats.
[Effects of high-load exercise induced skeletal muscle injury on autophagy ultrastructure and Beclin1 and LC3-II / I in rats].
Title: [Effects of high-load exercise induced skeletal muscle injury on autophagy ultrastructure and Beclin1 and LC3-II / I in rats].
our study provides evidence that the downregulation of ANXA3 promotes the repair and healing of myocardial tissues by activating the PI3K/Akt signaling pathway.
Title: Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction.
LC3-II expression increases following treatment with everolimus in combination with radiation and the radiosensitizing effects of everolimus are reversed by transfection with Beclin 1 siRNA.
Title: Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway.
daunorubicin-induced cardiac cytotoxicity is associated with upregulation of the E3 ligases, MURF-1 and MAFbx and also caused significant increases in two markers of autophagy, beclin-1 and LC3
Title: Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart.
The differential expression of Annexin A3 may play an important role in the development of hypospadia.
Title: [Proteomic analysis of the testis and differential expression of Annexin A3 in hypospadiac rats].
Expression of Beclin1 and LC3 in normal rat skin or immediately after injury stayed at a very low level, but levels started to elevate 6 hours after injury and showed increasingly strong expression at post injury time of day 3, day 5 and day 7.
Title: [Expression of beclin1 and LC3 after rat's skin contusion].
Aged rats had more newly proliferating cells expressing ANXA3 than young rats do.
Title: Annexin A3 expression after stroke in the aged rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

AA998890 (e-PCR)
- UniSTS:248632

RH129015 (e-PCR)
- UniSTS:212323

BF399376 (e-PCR)
- UniSTS:247661

RH94682 (e-PCR)
- UniSTS:119929

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A3

Names: 35-alpha calcimedin; Annexin III (Lipocortin III); PAP-III; annexin-3; lipocortin III; placental anticoagulant protein III

NP_036955.2

EC 3.1.4.43

XP_006250758.1

EC 3.1.4.43

XP_038947560.1

EC 3.1.4.43

XP_063128938.1

EC 3.1.4.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.