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    Boc BOC cell adhesion associated, oncogene regulated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bocprovided by RGD
    Official Full Name
    BOC cell adhesion associated, oncogene regulatedprovided by RGD
    Primary source
    RGD:1304550
    See related
    EnsemblRapid:ENSRNOG00000002041 AllianceGenome:RGD:1304550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in axon guidance; cell-cell adhesion; and positive regulation of myoblast differentiation. Predicted to act upstream of or within cell projection organization and smoothened signaling pathway. Located in axonal growth cone. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 88.3), Heart (RPKM 82.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Boc in Genome Data Viewer
    Location:
    11q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69628703..69704009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56122697..56198060)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61084216..61159220)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693572 Neighboring gene uncharacterized LOC134481000 Neighboring gene uncharacterized LOC102552306 Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC120095657 Neighboring gene uncharacterized LOC134481069

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, et al. Genes Dev, 2010 Sep 15. PMID 20844013, Free PMC Article
    2. Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. Fabre PJ, et al. J Neurosci, 2010 Jan 6. PMID 20053908, Free PMC Article
    3. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Zhang W, et al. Dev Cell, 2006 May. PMID 16647303
    4. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. Kang JS, et al. EMBO J, 2002 Jan 15. PMID 11782431, Free PMC Article
    5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, et al. Science, 2008 Sep 26. PMID 18772397, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    brother of CDO
    Names
    biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108317.2 → NP_001101787.2  brother of CDO precursor

      Status: VALIDATED

      Source sequence(s)
      CB324285, JAXUCZ010000011
      UniProtKB/TrEMBL
      D4A0Z7
      Conserved Domains (7) summary
      smart00408
      Location:240 → 301
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:132 → 207
      IG; Immunoglobulin
      cd00063
      Location:601 → 692
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:480 → 554
      fn3; Fibronectin type III domain
      pfam07679
      Location:318 → 401
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:31 → 104
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:404 → 467
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69628703..69704009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598158.3 → XP_017453647.1  brother of CDO isoform X1

      Conserved Domains (7) summary
      smart00408
      Location:332 → 393
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:132 → 207
      IG_like; Immunoglobulin like
      cd00063
      Location:601 → 692
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:318 → 401
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:468 → 554
      fn3; Fibronectin type III domain
      pfam16625
      Location:404 → 467
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cl11960
      Location:243 → 301
      Ig; Immunoglobulin domain

    2. XM_017598159.3 → XP_017453648.1  brother of CDO isoform X2

      UniProtKB/TrEMBL
      A6IR03
      Related
      ENSRNOP00000002790.8, ENSRNOT00000002790.9
      Conserved Domains (7) summary
      smart00408
      Location:332 → 393
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:468 → 552
      FN3; Fibronectin type 3 domain
      smart00410
      Location:132 → 207
      IG_like; Immunoglobulin like
      cd00063
      Location:600 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:318 → 401
      I-set; Immunoglobulin I-set domain
      pfam16625
      Location:404 → 467
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cl11960
      Location:243 → 301
      Ig; Immunoglobulin domain

    3. XM_017598160.3 → XP_017453649.1  brother of CDO isoform X3

      UniProtKB/TrEMBL
      D4A0Z7
      Conserved Domains (7) summary
      smart00408
      Location:332 → 393
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:468 → 552
      FN3; Fibronectin type 3 domain
      smart00410
      Location:132 → 207
      IG_like; Immunoglobulin like
      cd00063
      Location:600 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:318 → 401
      I-set; Immunoglobulin I-set domain
      pfam16625
      Location:404 → 467
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cl11960
      Location:243 → 301
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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