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    Tc2n tandem C2 domains, nuclear [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tc2nprovided by RGD
    Official Full Name
    tandem C2 domains, nuclearprovided by RGD
    Primary source
    RGD:1563876
    See related
    EnsemblRapid:ENSRNOG00000004754 AllianceGenome:RGD:1563876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tac2-N; Mtac2d1
    Summary
    Predicted to be active in nucleus. Orthologous to human TC2N (tandem C2 domains, nuclear). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 266.2), Uterus (RPKM 65.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tc2n in Genome Data Viewer
    Location:
    6q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126526006..126622163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120761112..120856835, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125437767..125601408, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene neugrin, neurite outgrowth associated, pseudogene 2 Neighboring gene uncharacterized LOC134479250 Neighboring gene fibulin 5 Neighboring gene thyroid hormone receptor interactor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
    2. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. Antoni G, et al. BMC Med Genet, 2011 Aug 2. PMID 21810271, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tandem C2 domains nuclear protein
    Names
    membrane targeting (tandem) C2 domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025152.1 → NP_001020323.1  tandem C2 domains nuclear protein

      See identical proteins and their annotated locations for NP_001020323.1

      Status: VALIDATED

      Source sequence(s)
      BC088432
      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      126526006..126622163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112744.2 → XP_038968672.1  tandem C2 domains nuclear protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    2. XM_063262331.1 → XP_063118401.1  tandem C2 domains nuclear protein isoform X4

    3. XM_039112750.2 → XP_038968678.1  tandem C2 domains nuclear protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Related
      ENSRNOP00000006371.6, ENSRNOT00000006371.9
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    4. XM_063262332.1 → XP_063118402.1  tandem C2 domains nuclear protein isoform X4

    5. XM_039112747.2 → XP_038968675.1  tandem C2 domains nuclear protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    6. XM_008764836.2 → XP_008763058.1  tandem C2 domains nuclear protein isoform X2

      See identical proteins and their annotated locations for XP_008763058.1

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    7. XM_039112745.2 → XP_038968673.1  tandem C2 domains nuclear protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    8. XM_063262329.1 → XP_063118399.1  tandem C2 domains nuclear protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9B0, E9PTC2, Q5M7U8

    9. XM_063262322.1 → XP_063118392.1  tandem C2 domains nuclear protein isoform X1

    10. XM_063262323.1 → XP_063118393.1  tandem C2 domains nuclear protein isoform X1

    11. XM_063262325.1 → XP_063118395.1  tandem C2 domains nuclear protein isoform X1

    12. XM_063262324.1 → XP_063118394.1  tandem C2 domains nuclear protein isoform X1

    13. XM_063262327.1 → XP_063118397.1  tandem C2 domains nuclear protein isoform X1

    14. XM_063262328.1 → XP_063118398.1  tandem C2 domains nuclear protein isoform X1

    15. XM_063262330.1 → XP_063118400.1  tandem C2 domains nuclear protein isoform X3

    16. XM_063262326.1 → XP_063118396.1  tandem C2 domains nuclear protein isoform X1

    17. XM_039112746.2 → XP_038968674.2  tandem C2 domains nuclear protein isoform X1

    18. XM_039112753.2 → XP_038968681.2  tandem C2 domains nuclear protein isoform X5

    19. XM_039112754.2 → XP_038968682.2  tandem C2 domains nuclear protein isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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