Mep1a meprin A subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mep1aprovided by RGD
Official Full Name: meprin A subunit alphaprovided by RGD
Primary source: RGD:3080
See related: EnsemblRapid:ENSRNOG00000011022 AllianceGenome:RGD:3080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metallodipeptidase activity and metalloendopeptidase activity. Predicted to be involved in epidermal growth factor receptor ligand maturation. Part of meprin A complex. Orthologous to human MEP1A (meprin A subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1277.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (24971901..25001414)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17474634..17504147)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20048163..20077678)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

optimization of activity by pH and NaCl concentration and relevance to catalytic mechanism
Title: Probing the active sites and mechanisms of rat metalloproteases meprin A and B.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epidermal growth factor receptor ligand maturation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of meprin A complex	IDA Inferred from Direct Assay more info	PubMed
part_of meprin A complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: meprin A subunit alpha

Names: E-24.18; MEP-1; endopeptidase-2; endopeptidase-24.18 subunit alpha; meprin 1 alpha; meprin 1 subunit alpha; meprin A alpha

NP_037275.1

EC 3.4.24.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013143.1 → NP_037275.1 meprin A subunit alpha precursor

See identical proteins and their annotated locations for NP_037275.1

Status: PROVISIONAL

Source sequence(s)

S43408

UniProtKB/Swiss-Prot

Q64230, Q642C9

Related

ENSRNOP00000014791.5, ENSRNOT00000014791.9

Conserved Domains (6) summary

cd06263
Location:270 → 432

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam00008
Location:676 → 710

EGF; EGF-like domain

pfam00629
Location:270 → 433

MAM; MAM domain, meprin/A5/mu

pfam01400
Location:75 → 261

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:32 → 260

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

cl02446
Location:432 → 596

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...