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Pax6 paired box 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25509, updated on 9-Dec-2024

Summary

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Official Symbol: Pax6provided by RGD
Official Full Name: paired box 6provided by RGD
Primary source: RGD:3258
See related: EnsemblRapid:ENSRNOG00000004410 AllianceGenome:RGD:3258
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including enteroendocrine cell differentiation; nervous system development; and positive regulation of macromolecule biosynthetic process. Located in chromatin. Used to study autistic disorder. Biomarker of Smith-Lemli-Opitz syndrome and transient cerebral ischemia. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 32.2) See more
Orthologs: human mouse all
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Genomic context

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See Pax6 in Genome Data Viewer

Location:: 3q33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (112590034..112611771)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (92128772..92157022)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (95700241..95728682)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAX6/CXCL14 regulatory axis promotes the repair of corneal injury by enhancing corneal epithelial cell proliferation.
Title: PAX6/CXCL14 regulatory axis promotes the repair of corneal injury by enhancing corneal epithelial cell proliferation.
Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.
Title: Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.
Results demonstrate that the miR-365-PAX6 system regulates the conversion of astrocytes into neurons in the ischemic brain. Both exogenous expression of PAX6 and administration of miR-365 antagomir are likely to promote brain repair by enhancing neurogenesis in adult mammalian brain following ischemic injury.
Title: MicroRNA-365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6.
Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period.
Title: Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.
These results suggest that Pax6 immunoreactivity showed diverse patterns in the neurogenic zone after prenatal hypoxia and Pax6 has important effects on neurogenesis
Title: Regional Immunoreactivity of Pax6 in the Neurogenic Zone After Chronic Prenatal Hypoxia.
analysis of the effect of Pax6 mutation on brain morphology and sex differences
Title: Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry.
High-fat diet feeding during pregnancy may induce insulin resistance in maternal rats by inhibiting pancreatic Pax6 and its target genes expression.
Title: High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway.
Up-regulation of Pax6 in neural progenitor cells plays an essential role in valproate-induced glutamatergic differentiation.
Title: Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring.
High glucose suppresses Pax6 expression in pancreatic beta-cells.
Title: Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells.
Pax6-transfected cells exhibited a similar growth curve (P>0.05), suggesting that the Pax6 5a has a similar effect on the proliferation of rMSCs as Pax6
Title: Cloning, expression, and functional characterization of the rat Pax6 5a orthologous splicing variant.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Bir2 (e-PCR), detects polymorphism
- UniSTS:141835

GDB:344354 (e-PCR)
- UniSTS:156688

GDB:197570 (e-PCR)
- UniSTS:155949

Pax6 (e-PCR), detects polymorphism
- UniSTS:238168

PMC186446P1 (e-PCR)
- UniSTS:271709

RH94662 (e-PCR)
- UniSTS:119909

RH94663 (e-PCR)
- UniSTS:119910

Pax6 (e-PCR), detects polymorphism
- UniSTS:265609

Pax6 (e-PCR), detects polymorphism
- UniSTS:265610

Pax6 (e-PCR), detects polymorphism
- UniSTS:466070

Pax6 (e-PCR), detects polymorphism
- UniSTS:507116

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	IEA Inferred from Electronic Annotation more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IEA Inferred from Electronic Annotation more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables co-SMAD binding	IEA Inferred from Electronic Annotation more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex regionalization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex regionalization	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex regionalization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in commitment of neuronal cell to specific neuron type in forebrain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain	ISO Inferred from Sequence Orthology more info
involved_in cornea development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in eye photoreceptor cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within eye photoreceptor cell development	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in forebrain dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
involved_in forebrain-midbrain boundary formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain-midbrain boundary formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of glandular epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in habenula development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habenula development	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	IDA Inferred from Direct Assay more info	PubMed
involved_in hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iris morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in iris morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in lacrimal gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lacrimal gland development	ISO Inferred from Sequence Orthology more info
involved_in learned vocalization behavior or vocal learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory bulb mitral cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pallium development	ISO Inferred from Sequence Orthology more info
involved_in pancreatic A cell development	IEA Inferred from Electronic Annotation more info
involved_in pancreatic A cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pancreatic A cell development	ISO Inferred from Sequence Orthology more info
involved_in pancreatic A cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamatergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to organelle	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regionalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of asymmetric cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of asymmetric cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of timing of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of timing of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in rhombomere morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in sensory neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction involved in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within telencephalon regionalization	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in type B pancreatic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paired box protein Pax-6

Names: oculorhombin; paired box gene 6; paired box homeotic gene 6

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013001.2 → NP_037133.1 paired box protein Pax-6

See identical proteins and their annotated locations for NP_037133.1

Status: PROVISIONAL

Source sequence(s)

BC128741

UniProtKB/Swiss-Prot

A1A5N7, P63016, Q6QHS5, Q701Q8

UniProtKB/TrEMBL

E1AZB1

Related

ENSRNOP00000005882.3, ENSRNOT00000005882.7

Conserved Domains (2) summary

smart00351
Location:4 → 128

PAX; Paired Box domain

pfam00046
Location:214 → 266

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

112590034..112611771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234633.5 → XP_006234695.1 paired box protein Pax-6 isoform X1

See identical proteins and their annotated locations for XP_006234695.1

UniProtKB/TrEMBL

E1AZB1

Related

ENSRNOP00000071013.2, ENSRNOT00000089525.3

Conserved Domains (2) summary

smart00351
Location:4 → 142

PAX; Paired Box domain

pfam00046
Location:228 → 281

Homeobox; Homeobox domain
XM_063283158.1 → XP_063139228.1 paired box protein Pax-6 isoform X2

UniProtKB/Swiss-Prot

A1A5N7, P63016, Q6QHS5, Q701Q8

UniProtKB/TrEMBL

E1AZB1
XM_039104376.2 → XP_038960304.1 paired box protein Pax-6 isoform X1

UniProtKB/TrEMBL

E1AZB1

Conserved Domains (2) summary

smart00351
Location:4 → 142

PAX; Paired Box domain

pfam00046
Location:228 → 281

Homeobox; Homeobox domain