Npy4r neuropeptide Y receptor Y4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npy4rprovided by RGD
Official Full Name: neuropeptide Y receptor Y4provided by RGD
Primary source: RGD:61864
See related: AllianceGenome:RGD:61864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppyr1
Summary: Enables pancreatic polypeptide receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Orthologous to several human genes including NPY4R (neuropeptide Y receptor Y4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 16p15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9474051..9475307, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9467801..9469057, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10489450..10490706, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of neuropeptide receptor NPY4R in rat retina.
Title: Localization of neuropeptide receptor NPY4R in rat retina.
results suggest that refeeding stimulates the expression of Y4R gene in the brainstem and that leptin may be one of the peripheral factors involved in this anorectic signaling mechanism [NPY4R]
Title: Up-regulation of neuropeptide Y Y4 receptor mRNA expression in the brainstem of refed rats following 48 h of food deprivation: effect of leptin.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pancreatic polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuropeptide Y receptor type 4

Names: NPY4-R; PP1; pancreatic polypeptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031581.2 → NP_113769.1 neuropeptide Y receptor type 4

See identical proteins and their annotated locations for NP_113769.1

Status: PROVISIONAL

Source sequence(s)

U42388

UniProtKB/Swiss-Prot

Q62892, Q63447

UniProtKB/TrEMBL

A6KFT0

Conserved Domains (2) summary

pfam00001
Location:58 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 221

7tm_4; Olfactory receptor