Apoh apolipoprotein H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apohprovided by RGD
Official Full Name: apolipoprotein Hprovided by RGD
Primary source: RGD:1310625
See related: EnsemblRapid:ENSRNOG00000003566 AllianceGenome:RGD:1310625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in cell surface and extracellular space. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 20360.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (93841992..93855897)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (93342435..93356334)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (96640013..96653939)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

New insight into antiphospholipid syndrome: antibodies to beta2glycoprotein I-domain 5 fail to induce thrombi in rats.
Title: New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats.
Increased levels of beta2-glycoprotein I-specific antibodies were found in sera of preeclamptic women
Title: Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies.
beta2-glycoprotein I causes antibodies to form which trigger coagulation subsequent to a priming proinflammatory factor, which is mediated by terminal C complex
Title: Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activator activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation, intrinsic pathway	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, intrinsic pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of respiratory burst	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in response to triglyceride	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-2-glycoprotein 1

Names: B2GPI; apo-H; beta(2)GPI; beta-2-glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009626.1 → NP_001009626.1 beta-2-glycoprotein 1 precursor

See identical proteins and their annotated locations for NP_001009626.1

Status: PROVISIONAL

Source sequence(s)

BC088180

UniProtKB/Swiss-Prot

P26644

UniProtKB/TrEMBL

A6HK92, F7FC04, Q5I0M1

Related

ENSRNOP00000107954.1, ENSRNOT00000151332.1

Conserved Domains (2) summary

PHA02927
Location:41 → 260

PHA02927; secreted complement-binding protein; Provisional

pfam09014
Location:261 → 345

Sushi_2; Beta-2-glycoprotein-1 fifth domain