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Fgfr1 Fibroblast growth factor receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79114, updated on 27-Nov-2024

Summary

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Official Symbol: Fgfr1provided by RGD
Official Full Name: Fibroblast growth factor receptor 1provided by RGD
Primary source: RGD:620713
See related: EnsemblRapid:ENSRNOG00000016050 AllianceGenome:RGD:620713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MFR; c-fgr; FGFR-1; bFGF-R; bFGF-R-1
Summary: Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Located in perinuclear region of cytoplasm. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; sciatic neuropathy; vascular dementia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 185.8), Lung (RPKM 166.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Fgfr1 in Genome Data Viewer

Location:: 16q12.4

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (73194631..73249855, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66491930..66547161, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (71265390..71319046, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats.
Title: Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats.
A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition.
Title: A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition.
Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway.
Title: Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway.
Suboptimal FGFR activation by a weak FGF1-FGFR dimer is sufficient to evoke a metabolic response, whereas full FGFR activation by stable and sustained dimerization is required to elicit a mitogenic response.
Title: Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.
To detect FGFR phosphorylation (pFGFR) levels and M1R-FGFR1 heteroreceptor complexes.
Title: Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures.
In summary, high FGF23 levels increase FGFR1, whereas phosphaturia decreases Klotho expression through the activation of Wnt/beta-catenin pathway.
Title: Differential regulation of renal Klotho and FGFR1 in normal and uremic rats.
It plays an important role as a key trigger of Intramuscular adipose tissue formation in vivo.
Title: Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells.
FGFR-1 inhibition with PD173074 ameliorated pulmonary arterial hypertension and vascular remodeling, and rescued BMPR-II expression.
Title: Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression.
we show that overexpression of FGFR1 in vitro resulted in decreased neurite outgrowth compared to control. Thus, our results suggest that the FGFR1 is not a suitable therapeutic target after SCI
Title: Overexpression of the Fibroblast Growth Factor Receptor 1 (FGFR1) in a Model of Spinal Cord Injury in Rats.
Activation of FGFR1 is essential for the high levels of FGF23 in acute and chronic experimental uremia.
Title: The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:534560

BF400869 (e-PCR)
- UniSTS:245046

D16Wox23 (e-PCR)
- UniSTS:519005

D16Wox22 (e-PCR)
- UniSTS:240559

PMC154461P1 (e-PCR)
- UniSTS:271314

AU047379 (e-PCR)
- UniSTS:110565

Fgfr1 (e-PCR), detects polymorphism
- UniSTS:143097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor receptor activity	TAS Traceable Author Statement more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within auditory receptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to histamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cementum mineralization	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within generation of neurons	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in orbitofrontal cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ induction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outer ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatic stellate cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in postnatal olfactory bulb interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphorus metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in tangential migration from the subventricular zone to the olfactory bulb	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ventricular zone neuroblast division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vitamin D3 metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor receptor 1

Names: FGF receptor-1; basic fibroblast growth factor receptor 1; proto-oncogene c-Fgr

NP_077060.2

EC 2.7.10.1

XP_006253385.1

EC 2.7.10.1

XP_006253389.1

EC 2.7.10.1

XP_038950779.1

EC 2.7.10.1

XP_063131817.1

EC 2.7.10.1

XP_063131818.1

EC 2.7.10.1

XP_063131819.1

EC 2.7.10.1

XP_063131820.1

EC 2.7.10.1

XP_063131821.1

EC 2.7.10.1

XP_063131822.1

EC 2.7.10.1

XP_063131823.1

EC 2.7.10.1

XP_063131824.1

EC 2.7.10.1

XP_063131825.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024146.2 → NP_077060.2 fibroblast growth factor receptor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

F1LM54

Related

ENSRNOP00000036885.5, ENSRNOT00000029284.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

73194631..73249855 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253327.3 → XP_006253389.1 fibroblast growth factor receptor 1 isoform X8

See identical proteins and their annotated locations for XP_006253389.1

UniProtKB/TrEMBL

A0A8J8YIL8, F1LPM6, Q63827

Related

ENSRNOP00000043459.4, ENSRNOT00000050980.7

Conserved Domains (5) summary

cd05098
Location:371 → 672

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam18123
Location:280 → 309

FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

cd00096
Location:164 → 167

Ig; Ig strand A [structural motif]

cd05857
Location:62 → 156

IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains

cl11960
Location:164 → 268

Ig; Immunoglobulin domain
XM_063275755.1 → XP_063131825.1 fibroblast growth factor receptor 1 isoform X7
XM_063275754.1 → XP_063131824.1 fibroblast growth factor receptor 1 isoform X6
XM_063275753.1 → XP_063131823.1 fibroblast growth factor receptor 1 isoform X5
XM_039094851.2 → XP_038950779.1 fibroblast growth factor receptor 1 isoform X4

UniProtKB/Swiss-Prot

Q04589

Conserved Domains (6) summary

cd05098
Location:460 → 761

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam18123
Location:369 → 398

FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

cd00096
Location:253 → 256

Ig; Ig strand A [structural motif]

cd04973
Location:25 → 118

IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains

cd05857
Location:151 → 245

IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains

cl11960
Location:253 → 357

Ig; Immunoglobulin domain
XM_063275751.1 → XP_063131821.1 fibroblast growth factor receptor 1 isoform X3
XM_006253323.5 → XP_006253385.1 fibroblast growth factor receptor 1 isoform X2

UniProtKB/Swiss-Prot

Q04589

Conserved Domains (7) summary

cd04973
Location:40 → 118

Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd04974
Location:270 → 359

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:163 → 247

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

smart00410
Location:262 → 358

IG_like; Immunoglobulin like

pfam07679
Location:160 → 247

I-set; Immunoglobulin I-set domain

cd05098
Location:462 → 763

PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

pfam07714
Location:476 → 752

Pkinase_Tyr; Protein tyrosine kinase
XM_063275747.1 → XP_063131817.1 fibroblast growth factor receptor 1 isoform X1

UniProtKB/TrEMBL

F1LM54
XM_063275749.1 → XP_063131819.1 fibroblast growth factor receptor 1 isoform X1

UniProtKB/TrEMBL

F1LM54
XM_063275752.1 → XP_063131822.1 fibroblast growth factor receptor 1 isoform X3
XM_063275750.1 → XP_063131820.1 fibroblast growth factor receptor 1 isoform X1

UniProtKB/TrEMBL

F1LM54
XM_063275748.1 → XP_063131818.1 fibroblast growth factor receptor 1 isoform X1

UniProtKB/TrEMBL

F1LM54