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    Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcns1provided by RGD
    Official Full Name
    potassium voltage-gated channel, modifier subfamily S, member 1provided by RGD
    Primary source
    RGD:621524
    See related
    EnsemblRapid:ENSRNOG00000013681 AllianceGenome:RGD:621524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv9.1
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 17.3), Lung (RPKM 1.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcns1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173255028..173262432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152835642..152843032, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160554423..160561820, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene serine/threonine kinase 4 Neighboring gene uncharacterized LOC108350520 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury. Tsantoulas C, et al. J Neurosci, 2012 Nov 28. PMID 23197740, Free PMC Article
    2. Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Stocker M, et al. Biochem Biophys Res Commun, 1998 Jul 30. PMID 9704029
    3. Electrically silent potassium channel subunits from human lens epithelium. Shepard AR, et al. Am J Physiol, 1999 Sep. PMID 10484328
    4. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, et al. Acta Neuropathol Commun, 2016 Aug 4. PMID 27487831, Free PMC Article
    5. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    delayed-rectifier potassium channel regulatory subunit KCNS1; potassium voltage-gated channel subfamily S member 1
    Names
    K+ voltage-gated channel, subfamily S, 1
    delayed-rectifier K(+) channel alpha subunit 1
    delayed-rectifier potassium channel subunit Kv9.1
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
    voltage-gated potassium channel subunit Kv9.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053954.2 → NP_446406.1  delayed-rectifier potassium channel regulatory subunit KCNS1

      See identical proteins and their annotated locations for NP_446406.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88758
      UniProtKB/TrEMBL
      A6JX60
      Related
      ENSRNOP00000018364.2, ENSRNOT00000018364.5
      Conserved Domains (4) summary
      smart00225
      Location:23 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:238 → 439
      Ion_trans; Ion transport protein
      pfam02214
      Location:21 → 120
      BTB_2; BTB/POZ domain
      pfam07885
      Location:355 → 433
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173255028..173262432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591433.3 → XP_017446922.1  potassium voltage-gated channel subfamily S member 1 isoform X1

      UniProtKB/Swiss-Prot
      O88758
      UniProtKB/TrEMBL
      A6JX60
      Conserved Domains (4) summary
      smart00225
      Location:23 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:238 → 439
      Ion_trans; Ion transport protein
      pfam02214
      Location:21 → 120
      BTB_2; BTB/POZ domain
      pfam07885
      Location:355 → 433
      Ion_trans_2; Ion channel

    2. XM_006235509.5 → XP_006235571.1  potassium voltage-gated channel subfamily S member 1 isoform X1

      See identical proteins and their annotated locations for XP_006235571.1

      UniProtKB/Swiss-Prot
      O88758
      UniProtKB/TrEMBL
      A6JX60
      Conserved Domains (4) summary
      smart00225
      Location:23 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:238 → 439
      Ion_trans; Ion transport protein
      pfam02214
      Location:21 → 120
      BTB_2; BTB/POZ domain
      pfam07885
      Location:355 → 433
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88758.1 GenPept UniProtKB/Swiss-Prot:O88758

    Gene LinkOut

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