Kng2 kininogen 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kng2provided by RGD
Official Full Name: kininogen 2provided by RGD
Primary source: RGD:2980
See related: EnsemblRapid:ENSRNOG00000065935 AllianceGenome:RGD:2980
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kng; Tkg; Kng1; Kngk; Kngt; Map1; TKG6; KINKG; KINKH; Kngt1; KINT1G; Kng_v1; Kng1_v1
Summary: Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of T cell proliferation; positive regulation of cell population proliferation; and regulation of protein metabolic process. Located in extracellular space and perikaryon. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 21287.7) See more
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Genomic context

Location:: 11q23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (91418470..91440841)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (77913876..77936247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (81509185..81516759)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the results suggest that the kallikrein-kinin system (KKS) plays a role in the effects of radiation on cardiac function and recruitment of inflammatory cells.
Title: Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system.
Bradykinin released during exercise triggers development of muscular mechanical hyperalgesia.
Title: Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness).
High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury.
Title: Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.
Bradykinin (KNG1) exerts a proinflammatory role in local and remote inflammation during experimental acute pancreatitis.
Title: Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
like filarial cystatins, T-KG inhibits ERK-dependent T cell proliferation, which suggests that it might have a role in immunosenescence
Title: T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation.
angiogenesis in deficiency
Title: Suppressed angiogenesis in kininogen-deficiencies.
a mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation
Title: The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation.
Plasma high molecular weight kininogen is key mediator of acute and chronic inflammatory arthritis in genetically susceptible Lewis rats.
Title: Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis.

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General gene information

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Markers

D11MIT8 (e-PCR)
- UniSTS:120144

RH127328 (e-PCR)
- UniSTS:210638

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Factor XII activation	IDA Inferred from Direct Assay more info	PubMed
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-kininogen 1

Names: K-kininogen, differential splicing leads to HMW Kngk; LMW T-kininogen I; T-kininogen I; alpha-1-MAP; kininogen 1; kininogen II; major acute phase protein; thiostatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.