Slc29a1 solute carrier family 29 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc29a1provided by RGD
Official Full Name: solute carrier family 29 member 1provided by RGD
Primary source: RGD:61899
See related: EnsemblRapid:ENSRNOG00000019752 AllianceGenome:RGD:61899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ENT1; rENT1
Summary: Enables uridine transmembrane transporter activity. Involved in several processes, including excitatory postsynaptic potential; lactation; and uridine transmembrane transport. Located in basolateral plasma membrane. Is active in postsynapse and presynapse. Used to study brain ischemia. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 352.7), Heart (RPKM 88.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (22897099..22911640)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (15399661..15414203)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (17784468..17799008)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
Title: Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.
ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats.
Title: ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats.
Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake.
Title: Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake.
Based on these results, we suggest that XNJI promotes arousal by inhibiting adenosine neurotransmission via reducing adenosine level and the expression of A1R and ENT1.
Title: Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats.
The present study demonstrates that ENT1 and adenosine constitute biomarkers of the initial stages of neurodegeneration in HD disease and also predicts that ENT1 could constitute a new therapeutic target to delay the progression of the disease.
Title: Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells.
Title: Localization of nucleoside transporters in rat epididymis.
Brains from rats with pilocarpine-induced seizures had high levels of ENT1. An ENT1 inhibitor suppressed neuronal firing and mEPSCs and deactivated phospho-CREB.
Title: ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission.
ENT1 expression in taste cells is important for elucidation of complicated taste signaling.
Title: Expression of equilibrative nucleoside transporter 1 in rat circumvallate papillae.
These findings indicate that high glucose suppresses the expression of ENT1 in cardiac fibroblasts by nitric oxide independent manner involving the signaling through PKC-zeta, Raf-1, MEK, and p38 MAPK pathways.
Title: High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases.
This report is the first detailed account of the expression and cellular distribution of ENT1 in rat dorsal horn and sensory ganglia.
Title: Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uracil transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenine transport	ISO Inferred from Sequence Orthology more info
involved_in adenine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thymine transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: equilibrative nucleoside transporter 1

Names: NBMPR-sensitive equilibrative nucleoside transporter; equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; nucleoside transporter, es-type; solute carrier family 29 (equilibrative nucleoside transporter), member 1; solute carrier family 29 (nucleoside transporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432780.1 → NP_001419709.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432781.1 → NP_001419710.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432782.1 → NP_001419711.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432783.1 → NP_001419712.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432784.1 → NP_001419713.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432785.1 → NP_001419714.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432786.1 → NP_001419715.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432787.1 → NP_001419716.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432788.1 → NP_001419717.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432789.1 → NP_001419718.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698
NM_001432790.1 → NP_001419719.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_001432791.1 → NP_001419720.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_001432792.1 → NP_001419721.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_031684.3 → NP_113872.1 equilibrative nucleoside transporter 1 isoform 1

See identical proteins and their annotated locations for NP_113872.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O54698

UniProtKB/TrEMBL

A0A8L2QGW6

Related

ENSRNOP00000026831.7, ENSRNOT00000026831.7

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

22897099..22911640

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244563.5 → XP_006244625.1 equilibrative nucleoside transporter 1 isoform X1

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_006244560.4 → XP_006244622.1 equilibrative nucleoside transporter 1 isoform X1

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_006244561.4 → XP_006244623.1 equilibrative nucleoside transporter 1 isoform X1

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_006244562.5 → XP_006244624.1 equilibrative nucleoside transporter 1 isoform X1

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_039084162.2 → XP_038940090.1 equilibrative nucleoside transporter 1 isoform X1

Conserved Domains (1) summary

TIGR00939
Location:18 → 457

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_063267671.1 → XP_063123741.1 equilibrative nucleoside transporter 1 isoform X1

UniProtKB/Swiss-Prot

O54698

Related

ENSRNOP00000085028.2, ENSRNOT00000107209.2