Tpp2 tripeptidyl peptidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpp2provided by RGD
Official Full Name: tripeptidyl peptidase 2provided by RGD
Primary source: RGD:621584
See related: EnsemblRapid:ENSRNOG00000011194 AllianceGenome:RGD:621584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TPP-2
Summary: Enables peptide binding activity and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 247.0), Spleen (RPKM 243.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (53538788..53620253)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (46046712..46128157)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (50578868..50628943) , (50664048..50744803)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the activity of TPP II play an important role in the pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension.
Title: [The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension].
increase of expression and activity in skeletal muscle during sepsis
Title: Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables tripeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tripeptidyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables tripeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular amino acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripeptidyl-peptidase 2

Names: TPP-II; tripeptidyl aminopeptidase; tripeptidyl-peptidase II

NP_112399.1

EC 3.4.14.10

XP_006244914.2

EC 3.4.14.10

XP_006244915.2

EC 3.4.14.10

XP_063123843.1

EC 3.4.14.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031137.2 → NP_112399.1 tripeptidyl-peptidase 2

See identical proteins and their annotated locations for NP_112399.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q64560

UniProtKB/TrEMBL

A0A8L2R9L9, A6INR9

Conserved Domains (2) summary

cd04857
Location:14 → 489

Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II

pfam12580
Location:777 → 963

TPPII; Tripeptidyl peptidase II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

53538788..53620253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244852.5 → XP_006244914.2 tripeptidyl-peptidase 2 isoform X1

UniProtKB/TrEMBL

A0A8L2R9L9, A6INR8

Related

ENSRNOP00000015393.5, ENSRNOT00000015393.7

Conserved Domains (2) summary

cd04857
Location:14 → 489

Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II

pfam12580
Location:777 → 963

TPPII; Tripeptidyl peptidase II
XM_006244853.5 → XP_006244915.2 tripeptidyl-peptidase 2 isoform X2

UniProtKB/TrEMBL

A0A8L2R9L9
XM_063267773.1 → XP_063123843.1 tripeptidyl-peptidase 2 isoform X3