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    Pigb phosphatidylinositol glycan anchor biosynthesis, class B [ Mus musculus (house mouse) ]

    Gene ID: 55981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pigbprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Bprovided by MGI
    Primary source
    MGI:MGI:1891825
    See related
    Ensembl:ENSMUSG00000079469 AllianceGenome:MGI:1891825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pig-b
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and mannosylation. Predicted to act upstream of or within GPI anchor metabolic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 80. Orthologous to human PIGB (phosphatidylinositol glycan anchor biosynthesis class B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.0), frontal lobe adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigb in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72920639..72946973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (73015301..73039723, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 4 Neighboring gene predicted gene, 23567 Neighboring gene STARR-positive B cell enhancer ABC_E3843 Neighboring gene piercer of microtubule wall 2 Neighboring gene STARR-seq mESC enhancer starr_24620 Neighboring gene cell cycle progression 1 Neighboring gene Pigb opposite strand 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_24625 Neighboring gene STARR-seq mESC enhancer starr_24627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. Takahashi M, et al. EMBO J, 1996 Aug 15. PMID 8861954, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within GPI anchor metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPI mannosyltransferase 3
    Names
    GPI mannosyltransferase III
    GPI-MT-III
    involved in GPI-anchor biosynthesis
    phosphatidylinositol glycan, class B
    phosphatidylinositol-glycan biosynthesis class B protein
    NP_001397577.1
    NP_061377.2
    XP_006511350.1
    XP_011241075.1
    XP_036011033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410648.1 → NP_001397577.1  GPI mannosyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      AC158997
      UniProtKB/Swiss-Prot
      Q3U585, Q7TQ01, Q9JJQ0
      Related
      ENSMUSP00000139269.2, ENSMUST00000184035.8

    2. NM_018889.4 → NP_061377.2  GPI mannosyltransferase 3

      See identical proteins and their annotated locations for NP_061377.2

      Status: VALIDATED

      Source sequence(s)
      AC158997
      Consensus CDS
      CCDS40687.1
      UniProtKB/Swiss-Prot
      Q3U585, Q7TQ01, Q9JJQ0
      Related
      ENSMUSP00000138885.2, ENSMUST00000183746.8
      Conserved Domains (1) summary
      cl21590
      Location:39 → 529
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72920639..72946973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155140.1 → XP_036011033.1  GPI mannosyltransferase 3 isoform X2

      Conserved Domains (1) summary
      cl21590
      Location:159 → 416
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. XM_006511287.5 → XP_006511350.1  GPI mannosyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cl21590
      Location:51 → 254
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    3. XM_011242773.4 → XP_011241075.1  GPI mannosyltransferase 3 isoform X4

      Conserved Domains (1) summary
      cl21590
      Location:51 → 273
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RNA

    1. XR_379430.5 RNA Sequence

    2. XR_870761.4 RNA Sequence

    3. XR_379431.5 RNA Sequence

    4. XR_379429.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJQ0.2 GenPept UniProtKB/Swiss-Prot:Q9JJQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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