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    FAM219B family with sequence similarity 219 member B [ Homo sapiens (human) ]

    Gene ID: 57184, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FAM219Bprovided by HGNC
    Official Full Name
    family with sequence similarity 219 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:24695
    See related
    Ensembl:ENSG00000178761 AllianceGenome:HGNC:24695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C15orf17
    Expression
    Ubiquitous expression in fat (RPKM 16.4), prostate (RPKM 16.2) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See FAM219B in Genome Data Viewer
    Location:
    15q24.1-q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74897963..74906851, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72767844..72776732, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75192333..75199192, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75134491-75135016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75135085-75135996 Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene secretory carrier membrane protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75157901-75158832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75161878-75162388 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75162904-75163889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75182299-75182832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75191053-75191552 Neighboring gene mannose phosphate isomerase Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75197802-75198608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75198609-75199413 Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75246929-75247862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75247863-75248796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75248797-75249730 Neighboring gene ribonuclease P and MRP subunit p25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of long cDNA clones from human adult spleen. Hattori A, et al. DNA Res, 2000 Dec 31. PMID 11214971
    2. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    3. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM219B
    Names
    uncharacterized protein C15orf17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321920.2 → NP_001308849.1  protein FAM219B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), along with variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AC125435, BC064575
      Consensus CDS
      CCDS32295.1
      UniProtKB/Swiss-Prot
      A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
      UniProtKB/TrEMBL
      H3BRU1
      Related
      ENSP00000454719.1, ENST00000563119.5
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 198
      FAM219A; Protein family FAM219A

    2. NM_001321921.2 → NP_001308850.1  protein FAM219B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), along with variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC125435
      Consensus CDS
      CCDS32295.1
      UniProtKB/Swiss-Prot
      A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
      UniProtKB/TrEMBL
      H3BRU1
      Related
      ENSP00000456404.1, ENST00000563671.5
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 198
      FAM219A; Protein family FAM219A

    3. NM_001321922.2 → NP_001308851.1  protein FAM219B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), along with variant 5, encodes isoform b.
      Source sequence(s)
      AC125435
      UniProtKB/TrEMBL
      H3BRU1
      Related
      ENSP00000454277.1, ENST00000562698.5
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 197
      FAM219A; Protein family FAM219A

    4. NM_001321923.2 → NP_001308852.1  protein FAM219B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), along with variant 4, encodes isoform b.
      Source sequence(s)
      AC125435
      UniProtKB/TrEMBL
      H3BRU1
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 197
      FAM219A; Protein family FAM219A

    5. NM_020447.5 → NP_065180.1  protein FAM219B isoform a

      See identical proteins and their annotated locations for NP_065180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), along with variants 2 and 3, encodes isoform a.
      Source sequence(s)
      AC125435, DB153105
      Consensus CDS
      CCDS32295.1
      UniProtKB/Swiss-Prot
      A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
      UniProtKB/TrEMBL
      H3BRU1
      Related
      ENSP00000350260.5, ENST00000357635.10
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 198
      FAM219A; Protein family FAM219A

    RNA

    1. NR_135841.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    2. NR_135842.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    3. NR_135843.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    4. NR_135844.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    5. NR_135845.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    6. NR_135846.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    7. NR_135847.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    8. NR_135848.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435
      Related
      ENST00000569524.5

    9. NR_135849.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    10. NR_135850.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    11. NR_135851.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    12. NR_135852.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    13. NR_135853.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    14. NR_135854.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125435

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      74897963..74906851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022433.3 → XP_016877922.1  protein FAM219B isoform X2

      UniProtKB/TrEMBL
      H3BRU1
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 197
      FAM219A; Protein family FAM219A

    2. XM_047432883.1 → XP_047288839.1  protein FAM219B isoform X1

      UniProtKB/Swiss-Prot
      A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
      UniProtKB/TrEMBL
      H3BRU1

    3. XM_047432884.1 → XP_047288840.1  protein FAM219B isoform X2

      UniProtKB/TrEMBL
      H3BRU1

    RNA

    1. XR_007064481.1 RNA Sequence

    2. XR_243118.5 RNA Sequence

    3. XR_243117.5 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      72767844..72776732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378489.1 → XP_054234464.1  protein FAM219B isoform X2

      UniProtKB/TrEMBL
      H3BRU1

    2. XM_054378487.1 → XP_054234462.1  protein FAM219B isoform X1

      UniProtKB/Swiss-Prot
      A8K4Q5, B4DK57, Q5XKK7, Q9NXY0
      UniProtKB/TrEMBL
      H3BRU1

    3. XM_054378488.1 → XP_054234463.1  protein FAM219B isoform X2

      UniProtKB/TrEMBL
      H3BRU1

    RNA

    1. XR_008488998.1 RNA Sequence

    2. XR_008488997.1 RNA Sequence

    3. XR_008488996.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XKK7.1 GenPept UniProtKB/Swiss-Prot:Q5XKK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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