akt3a v-akt murine thymoma viral oncogene homolog 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: akt3aprovided by ZNC
Official Full Name: v-akt murine thymoma viral oncogene homolog 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-180
See related: Ensembl:ENSDARG00000104810 AllianceGenome:ZFIN:ZDB-GENE-050419-180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: akt3; si:ch211-221n23.2
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in response to peptide hormone. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in skeletal muscle. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (11175512..11378305, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (11043037..11245830, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

G46148 (e-PCR)
- UniSTS:106950

G39947 (e-PCR)
- UniSTS:81117

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RAC-gamma serine/threonine-protein kinase

Names: v-akt murine thymoma viral oncogene-like 3

NP_001184130.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197201.2 → NP_001184130.1 RAC-gamma serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_001184130.1

Status: PROVISIONAL

Source sequence(s)

HM147246

UniProtKB/TrEMBL

A0A8M1NX97, A0A8M9PXW5, D9IL79

Related

ENSDARP00000139879.1, ENSDART00000164566.2

Conserved Domains (4) summary

smart00220
Location:148 → 405

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:4 → 110

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05593
Location:132 → 479

STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

pfam00169
Location:6 → 105

PH; PH domain