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    cpne1 copine I [ Danio rerio (zebrafish) ]

    Gene ID: 324841, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cpne1provided by ZNC
    Official Full Name
    copine Iprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3562
    See related
    Ensembl:ENSDARG00000075536 AllianceGenome:ZFIN:ZDB-GENE-030131-3562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cpne3; cpne3l; zgc:55873; wu:fb69d07; wu:fc45a04
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Is expressed in epidermis; notochord; periderm; polster; and vasculature. Orthologous to human CPNE1 (copine 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See cpne1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (26375972..26401677)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (26138356..26164061)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene phosphopantothenoylcysteine synthetase Neighboring gene UTP3 small subunit processome component Neighboring gene RNA binding motif protein 12 Neighboring gene fer-1 like family member 4 Neighboring gene un-named sa1614

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example. Yang W, et al. BMC Genomics, 2008 Oct 3. PMID 18831769, Free PMC Article
    2. Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Ayobahan SU, et al. Chemosphere, 2020 Feb. PMID 31726584
    3. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    copine-1
    Names
    copine III, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276281.1 → NP_001263210.1  copine-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BX005135
      UniProtKB/TrEMBL
      A0A8M2BGH8, F1QNY5
      Related
      ENSDARP00000094289.3, ENSDART00000103513.5
      Conserved Domains (3) summary
      cd04047
      Location:139 → 251
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:263 → 515
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    2. NM_199699.2 → NP_955993.2  copine-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one exon and includes an alternate exon in the middle coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX005135
      UniProtKB/TrEMBL
      A0A8M1PA14, Q6TEN9
      Related
      ENSDARP00000082086.4, ENSDART00000087652.6
      Conserved Domains (3) summary
      cd04047
      Location:139 → 250
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:262 → 514
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      26375972..26401677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224112.1 → XP_068080213.1  copine-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M1PA14, Q6TEN9

    2. XM_068224111.1 → XP_068080212.1  copine-1 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGH8, F1QNY5
      Related
      ENSDARP00000140424.1, ENSDART00000171748.2

    3. XM_005169258.5 → XP_005169315.1  copine-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGH9
      Conserved Domains (3) summary
      cd04047
      Location:144 → 255
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:12 → 130
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:267 → 519
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    4. XM_005169257.5 → XP_005169314.1  copine-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BH47
      Conserved Domains (3) summary
      cd04047
      Location:144 → 256
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:12 → 130
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:268 → 520
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    5. XM_005169262.4 → XP_005169319.1  copine-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M1PA14, Q6TEN9
      Conserved Domains (3) summary
      cd04047
      Location:139 → 250
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:262 → 514
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    6. XM_005169260.5 → XP_005169317.1  copine-1 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGH8, F1QNY5
      Conserved Domains (3) summary
      cd04047
      Location:139 → 251
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:7 → 125
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:263 → 515
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    7. XM_017358205.3 → XP_017213694.1  copine-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z114
    Nucleotide Protein Strain
    Heading Accession and Version

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