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    lspA lipoprotein signal peptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944800, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lspA
    Official Full Name
    lipoprotein signal peptidase
    Primary source
    ECOCYC:EG10548
    Locus tag
    b0027
    See related
    ASAP:ABE-0000096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0028; lsp
    Summary
    The lspA gene encodes prolipoprotein signal peptidase (signal peptidase II) . [More information is available at EcoCyc: EG10548].
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    Genomic context

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    Sequence:
    NC_000913.3 (25207..25701)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene bifunctional riboflavin kinase/FMN adenylyltransferase Neighboring gene isoleucine--tRNA ligase Neighboring gene peptidyl-prolyl cis-trans isomerase FkpB Neighboring gene 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alternate pathway for the processing of the prolipoprotein signal peptide in Escherichia coli. Ghrayeb J, et al. J Biol Chem, 1985 Sep 15. PMID 2993296
    2. Rapid assay and purification of a unique signal peptidase that processes the prolipoprotein from Escherichia coli B. Dev IK, et al. J Biol Chem, 1984 Sep 10. PMID 6381496
    3. A distinct signal peptidase for prolipoprotein in Escherichia coli. Tokunaga M, et al. J Cell Biochem, 1984. PMID 6373799
    4. Prolipoprotein modification and processing enzymes in Escherichia coli. Tokunaga M, et al. J Biol Chem, 1984 Mar 25. PMID 6368552
    5. Temperature-sensitive prolipoprotein signal peptidase in an Escherichia coli mutant: use of the mutant for an efficient and convenient assay system. Yamagata H. J Biochem, 1983 Jun. PMID 6350278

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoprotein signal peptidase
    NP_414568.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      25207..25701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414568.1 lipoprotein signal peptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414568.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7RDY7
      Conserved Domains (1) summary
      PRK00376
      Location:2 → 160
      lspA; lipoprotein signal peptidase
    Nucleotide Protein
    Heading Accession and Version

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