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    tyrR DNA-binding transcriptional dual regulator TyrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945879, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tyrR
    Official Full Name
    DNA-binding transcriptional dual regulator TyrR
    Primary source
    ECOCYC:EG11042
    Locus tag
    b1323
    See related
    ASAP:ABE-0004440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1319
    Summary
    The protein belongs to the EBP family. [More information is available at EcoCyc: EG11042].
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    Genomic context

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    Sequence:
    NC_000913.3 (1386720..1388261)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YcjW Neighboring gene DUF463 domain-containing protein YcjX Neighboring gene DUF697 domain-containing inner membrane protein YcjF Neighboring gene lipid hydroperoxide peroxidase Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene murein tripeptide amidase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between the Escherichia coli Regulatory protein TyrR and DNA: a fluorescence footprinting study. Bailey M, et al. Biochemistry, 1995 Dec 5. PMID 7495812
    2. Backbone resonance assignment of the 2H, 13C, 15N labelled 32kDa central domain of Escherichia coli TyrR. Swarbrick JD, et al. J Biomol NMR, 2002 Apr. PMID 12018490
    3. The central domain of Escherichia coli TyrR is responsible for hexamerization associated with tyrosine-mediated repression of gene expression. Dixon MP, et al. J Biol Chem, 2002 Jun 28. PMID 11923293
    4. The sigma(70) transcription factor TyrR has zinc-stimulated phosphatase activity that is inhibited by ATP and tyrosine. Zhao S, et al. J Bacteriol, 2000 Feb. PMID 10648532, Free PMC Article
    5. A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli K-12. Cui J, et al. J Bacteriol, 1993 Mar. PMID 8449884, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
      Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    2. Residues at positions 160, 173 and 184 of TyrR protein are important for transcriptional activation of target genes tyrP induced by L-phenylalanine, which indicates that they are the bona fide L-phenylalanine binding sites of TyrR protein.
      Title: Pinpointing the L-phenylalanine binding sites of TyrR using biosensors and computer-aided simulation.
    3. N-terminus verified by Edman degradation on complete protein
      Title: The TyrR protein of Escherichia coli, analysis by limited proteolysis of domain structure and ligand-mediated conformational changes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator TyrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1386720..1388261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415839.1 DNA-binding transcriptional dual regulator TyrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415839.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X2C0
      Conserved Domains (1) summary
      PRK10820
      Location:1 → 513
      PRK10820; transcriptional regulator TyrR
    Nucleotide Protein
    Heading Accession and Version

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