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    ralR endodeoxyribonuclease toxin RalR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945914, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ralR
    Official Full Name
    endodeoxyribonuclease toxin RalR
    Primary source
    ECOCYC:EG11900
    Locus tag
    b1348
    See related
    ASAP:ABE-0004524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1345; lar; ydaB
    Summary
    lar, a Rac prophage gene found to be expressed in sbcA mutants of Escherichia coli, is involved in restriction alleviation and enhancement of modification by EcoKI , but not in restriction alleviation of type III restriction systems . [More information is available at EcoCyc: EG11900].
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    Genomic context

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    Sequence:
    NC_000913.3 (1413733..1413927, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative integrase Neighboring gene excisionase Neighboring gene double-strand break reduction protein Neighboring gene ncRNA Neighboring gene recombinase RecT Neighboring gene exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific Neighboring gene protein RacC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli. Guo Y, et al. Nucleic Acids Res, 2014 Jun. PMID 24748661, Free PMC Article
    2. Restriction alleviation by bacteriophages lambda and lambda reverse. Toothman P. J Virol, 1981 May. PMID 6264133, Free PMC Article
    3. Degradation of bacteriophage lambda deoxyribonucleic acid after restriction by Escherichia coli K-12. Simmon VF, et al. J Bacteriol, 1972 Oct. PMID 4562392, Free PMC Article
    4. Type III restriction is alleviated by bacteriophage (RecE) homologous recombination function but enhanced by bacterial (RecBCD) function. Handa N, et al. J Bacteriol, 2005 Nov. PMID 16237019, Free PMC Article
    5. Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recombination. Blakely GW, et al. Mol Microbiol, 2006 May. PMID 16677300

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RalR does not inhibit restriction modification but instead is part of a toxin/antitoxin system and functions as a non-specific DNase.
      Title: RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables double-stranded DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA restriction-modification system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endodeoxyribonuclease toxin RalR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1413733..1413927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415864.1 endodeoxyribonuclease toxin RalR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415864.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9HVS2
      Conserved Domains (1) summary
      PRK09710
      Location:1 → 64
      lar; type I toxin-antitoxin system endodeoxyribonuclease toxin RalR
    Nucleotide Protein
    Heading Accession and Version

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