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    fhuF ferric-siderophore reductase FhuF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948891, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fhuF
    Official Full Name
    ferric-siderophore reductase FhuF
    Primary source
    ECOCYC:G7949
    Locus tag
    b4367
    See related
    ASAP:ABE-0014326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4357; yjjS
    Summary
    CsdB (SufS) and SufD are required to insert an iron-sulfur cluster into FhuF. [More information is available at EcoGene: EG12595]. FhuF is likely to act in iron reduction during utilization of a ferrioxamine B iron source . [More information is available at EcoCyc: G7949].
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    Genomic context

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    Sequence:
    NC_000913.3 (4604875..4605663, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative succinate exporter YjjB Neighboring gene putative succinate exporter YjjP Neighboring gene DNA-binding transcriptional repressor YjjQ Neighboring gene DNA-binding transcriptional regulator BglJ Neighboring gene DUF1435 domain-containing protein YjjZ Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the ferrioxamine B receptor, FoxB, in Escherichia coli K12. Nelson M, et al. Biometals, 1992 Spring. PMID 1392471
    2. Selection procedure for deregulated iron transport mutants (fur) in Escherichia coli K 12: fur not only affects iron metabolism. Hantke K. Mol Gen Genet, 1987 Nov. PMID 3323834
    3. Structural, functional and mutational analysis of the pfr gene encoding a ferritin from Helicobacter pylori. Bereswill S, et al. Microbiology (Reading), 1998 Sep. PMID 9782498
    4. Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli. Trindade IB, et al. J Biol Inorg Chem, 2021 May. PMID 33559753, Free PMC Article
    5. Computation-directed identification of OxyR DNA binding sites in Escherichia coli. Zheng M, et al. J Bacteriol, 2001 Aug. PMID 11443092, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli.
      Title: Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on metal ions IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within reductive iron assimilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within reductive iron assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within siderophore-dependent iron import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric-siderophore reductase FhuF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4604875..4605663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418787.1 ferric-siderophore reductase FhuF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418787.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TQX2, A0A376FSA2
      Conserved Domains (1) summary
      PRK10647
      Location:1 → 262
      PRK10647; ferric iron reductase involved in ferric hydroximate transport; Provisional
    Nucleotide Protein
    Heading Accession and Version

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