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    paaA phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945833, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaA
    Official Full Name
    phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit
    Primary source
    ECOCYC:G6709
    Locus tag
    b1388
    See related
    ASAP:ABE-0004649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1385; ydbO
    Summary
    PaaABCDE is a multi-subunit oxygenase that hydroxylates phenylacetyl-CoA. [More information is available at EcoGene: EG13736]. PaaA, PaaB, PaaC, and PaaD are predicted to be subunits of a phenylacetate-CoA oxygenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6709].
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    Genomic context

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    Sequence:
    NC_000913.3 (1453927..1454856)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper-containing amine oxidase Neighboring gene fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B Neighboring gene phenylacetyl-CoA 1,2-epoxidase, structural subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, et al. J Biol Chem, 2011 Mar 25. PMID 21247899, Free PMC Article
    2. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Fernández C, et al. Appl Environ Microbiol, 2006 Nov. PMID 16997993, Free PMC Article
    3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    4. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
    5. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylacetyl-CoA 1,2-epoxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylacetate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of phenylacetyl-CoA 1,2-epoxidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit
    NP_415906.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1453927..1454856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415906.1 phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415906.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6G2B5H7, A0A6M9WR36, A0A8T5YG25
      Conserved Domains (1) summary
      PRK13778
      Location:1 → 302
      paaA; phenylacetate-CoA oxygenase subunit PaaA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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