PNO1 partner of NOB1 homolog [Homo sapiens (human)] - Gene

Summary

Official Symbol: PNO1provided by HGNC
Official Full Name: partner of NOB1 homologprovided by HGNC
Primary source: HGNC:HGNC:32790
See related: Ensembl:ENSG00000115946 MIM:618710; AllianceGenome:HGNC:32790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RRP20; KHRBP1
Summary: Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus and nucleoplasm. Part of small-subunit processome. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 8.8), adrenal (RPKM 8.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (68157888..68176238)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (68168438..68186793)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (68385020..68403370)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PNO1 promotes the progression of osteosarcoma via TGF-beta and YAP/TAZ pathway.
Title: PNO1 promotes the progression of osteosarcoma via TGF-β and YAP/TAZ pathway.
Partner of NOB1 homolog transcriptionally activated by E2F transcription factor 1 promotes the malignant progression and inhibits ferroptosis of pancreatic cancer.
Title: Partner of NOB1 homolog transcriptionally activated by E2F transcription factor 1 promotes the malignant progression and inhibits ferroptosis of pancreatic cancer.
Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application.
Title: Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application.
PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma.
Title: PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma.
Ribosome assembly factor PNO1 is associated with progression and promotes tumorigenesis in triplenegative breast cancer.
Title: Ribosome assembly factor PNO1 is associated with progression and promotes tumorigenesis in triple‑negative breast cancer.
PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity.
Title: PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity.
Knockdown of PNO1 inhibits esophageal cancer progression.
Title: Knockdown of PNO1 inhibits esophageal cancer progression.
PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
Title: PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
Importance of PNO1 for growth and survival of urinary bladder carcinoma: Role in core-regulatory circuitry.
Title: Importance of PNO1 for growth and survival of urinary bladder carcinoma: Role in core-regulatory circuitry.
High PNO1 expression is associated with colorectal cancer.
Title: EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S2828 (e-PCR)
- UniSTS:77138

D1S1423 (e-PCR)
- UniSTS:149619

SGC34128 (e-PCR)
- UniSTS:61125

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein PNO1

Names: KH-type RNA-binding protein 1; RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329916.2 → NP_001316845.1 RNA-binding protein PNO1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC017083

UniProtKB/TrEMBL

B2R823
NM_001329917.2 → NP_001316846.1 RNA-binding protein PNO1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC017083

UniProtKB/TrEMBL

B2R823
NM_020143.4 → NP_064528.1 RNA-binding protein PNO1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC017083, BC008304

Consensus CDS

CCDS1885.1

UniProtKB/Swiss-Prot

A8K6Q0, Q53G13, Q8WVB8, Q9NRX1

UniProtKB/TrEMBL

B2R823

Related

ENSP00000263657.2, ENST00000263657.7

Conserved Domains (2) summary

cd22391
Location:73 → 152

KH-I_PNO1_rpt1; first type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins

cd22392
Location:154 → 249

KH-I_PNO1_rpt2; second type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins

RNA

NR_138146.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC017083