Slc2a1 solute carrier family 2 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a1provided by RGD
Official Full Name: solute carrier family 2 member 1provided by RGD
Primary source: RGD:3704
See related: EnsemblRapid:ENSRNOG00000007284 AllianceGenome:RGD:3704
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GTG1; Gtg3; GLUTB; Glut1; RATGTG1
Summary: Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 185.1), Kidney (RPKM 121.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (138002522..138030742)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (132717196..132745416)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (138154677..138182897)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Title: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
Title: A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats.
Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats.
Title: Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats.
Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model.
Title: Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model.
Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats.
Title: Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats.
PPARgamma alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
Title: PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
Measurements of basal d-glucose transport through GLUT1 across the intact plasma membrane of isolated segments from single fast- and slow-twitch skeletal muscle fibres of rat.
Title: Measurements of basal d-glucose transport through GLUT1 across the intact plasma membrane of isolated segments from single fast- and slow-twitch skeletal muscle fibres of rat.
Cortical Dysplasia in Rats Provokes Neurovascular Alterations, GLUT1 Dysfunction, and Metabolic Disturbances That Are Sustained Post-Seizure Induction.
Title: Cortical Dysplasia in Rats Provokes Neurovascular Alterations, GLUT1 Dysfunction, and Metabolic Disturbances That Are Sustained Post-Seizure Induction.
Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
Title: Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure.
Title: Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:547329

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:144421

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:516693

D5Wox11 (e-PCR)
- UniSTS:118109

d5arb7 (e-PCR)
- UniSTS:122053

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	ISO Inferred from Sequence Orthology more info
part_of glucose transporter complex	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 1

Names: GLUT-1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; glucose transporter type 1, erythrocyte/brain; solute carrier family 2 (facilitated glucose transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138827.2 → NP_620182.1 solute carrier family 2, facilitated glucose transporter member 1

See identical proteins and their annotated locations for NP_620182.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P11167

UniProtKB/TrEMBL

A0A8I6ABD3, A6JZL0

Related

ENSRNOP00000061340.1, ENSRNOT00000064452.4

Conserved Domains (1) summary

cd17431
Location:14 → 458

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily