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    rnf141 ring finger protein 141 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308900, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rnf141provided by RGD
    Official Full Name
    ring finger protein 141provided by RGD
    Primary source
    RGD:1303154
    See related
    EnsemblRapid:ENSRNOG00000079384 AllianceGenome:RGD:1303154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in membrane. Orthologous to human RNF141 (ring finger protein 141). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 244.9), Brain (RPKM 168.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See rnf141 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (174365789..174391848, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164933972..164957081, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (175631656..175657485, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349612 Neighboring gene uncharacterized LOC103691204 Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The zinc finger domain of RING finger protein 141 reveals a unique RING fold. Miyamoto K, et al. Protein Sci, 2017 Aug. PMID 28547869, Free PMC Article
    2. Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. Qiu W, et al. Biochem Biophys Res Commun, 2003 Jun 27. PMID 12804569
    3. Protein microarray characterization of the S-nitrosoproteome. Lee YI, et al. Mol Cell Proteomics, 2014 Jan. PMID 24105792, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 141

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001800.1 → NP_001001800.1  RING finger protein 141

      Status: PROVISIONAL

      Source sequence(s)
      AY621087
      UniProtKB/Swiss-Prot
      Q6IV57
      UniProtKB/TrEMBL
      A6I825
      Related
      ENSRNOP00000112632.1, ENSRNOT00000157277.1
      Conserved Domains (2) summary
      TIGR00599
      Location:129 → 207
      rad18; DNA repair protein rad18
      cd16545
      Location:154 → 192
      RING-HC_RNF141; RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      174365789..174391848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262931.1 → XP_063119001.1  RING finger protein 141 isoform X1

      UniProtKB/Swiss-Prot
      Q6IV57
      UniProtKB/TrEMBL
      A6I825

    2. XM_063262934.1 → XP_063119004.1  RING finger protein 141 isoform X2

    3. XM_063262938.1 → XP_063119008.1  RING finger protein 141 isoform X4

      UniProtKB/TrEMBL
      A6I827

    4. XM_063262937.1 → XP_063119007.1  RING finger protein 141 isoform X3

    RNA

    1. XR_010052932.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IV57.1 GenPept UniProtKB/Swiss-Prot:Q6IV57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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