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    Cyb5rl cytochrome b5 reductase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyb5rlprovided by RGD
    Official Full Name
    cytochrome b5 reductase-likeprovided by RGD
    Primary source
    RGD:1597451
    See related
    EnsemblRapid:ENSRNOG00000009148 AllianceGenome:RGD:1597451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in nucleoplasm. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 187.0), Heart (RPKM 24.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyb5rl in Genome Data Viewer
    Location:
    5q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127075034..127097551)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (121846223..121868287)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126666934..126683069)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene single stranded DNA binding protein 3 Neighboring gene uncharacterized LOC134479027 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene uncharacterized LOC120102947 Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene CUB domain containing protein 2 Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene transfer RNA alanine (anticodon AGC) 38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b5 reductase-like
    Names
    NADH-cytochrome b5 reductase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411873.1 → NP_001398802.1  cytochrome b5 reductase-like

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000104550.1, ENSRNOT00000130338.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127075034..127097551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288433.1 → XP_063144503.1  cytochrome b5 reductase-like isoform X4

    2. XM_063288431.1 → XP_063144501.1  cytochrome b5 reductase-like isoform X2

    3. XM_063288434.1 → XP_063144504.1  cytochrome b5 reductase-like isoform X5

    4. XM_039111133.2 → XP_038967061.1  cytochrome b5 reductase-like isoform X6

      UniProtKB/TrEMBL
      A0A8I6A4C4, A6JYQ2
      Conserved Domains (2) summary
      cd06183
      Location:82 → 273
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    5. XM_063288435.1 → XP_063144505.1  cytochrome b5 reductase-like isoform X7

      UniProtKB/TrEMBL
      A6JYQ3

    6. XM_039111134.2 → XP_038967062.1  cytochrome b5 reductase-like isoform X8

      UniProtKB/TrEMBL
      A6JYQ2
      Related
      ENSRNOP00000037061.6, ENSRNOT00000036072.9
      Conserved Domains (2) summary
      cd06183
      Location:82 → 248
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    7. XM_039111129.2 → XP_038967057.1  cytochrome b5 reductase-like isoform X1

      Conserved Domains (2) summary
      cd06183
      Location:82 → 257
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    8. XM_039111132.2 → XP_038967060.1  cytochrome b5 reductase-like isoform X3

      Conserved Domains (2) summary
      cd06183
      Location:82 → 315
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    9. XM_039111130.2 → XP_038967058.1  cytochrome b5 reductase-like isoform X1

      Conserved Domains (2) summary
      cd06183
      Location:82 → 257
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    10. XM_063288436.1 → XP_063144506.1  cytochrome b5 reductase-like isoform X7

      UniProtKB/TrEMBL
      A6JYQ3

    11. XM_039111131.2 → XP_038967059.1  cytochrome b5 reductase-like isoform X1

      Conserved Domains (2) summary
      cd06183
      Location:82 → 257
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:16 → 51
      Oxidored-like; Oxidoreductase-like protein, N-terminal

    12. XM_063288430.1 → XP_063144500.1  cytochrome b5 reductase-like isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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