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    Derl3 derlin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690315, updated on 4-Jan-2025

    Summary

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    Symbol
    Derl3provided by RGD
    Full Name
    derlin 3provided by RGD
    Primary source
    RGD:1597373
    See related
    EnsemblRapid:ENSRNOG00000028243 AllianceGenome:RGD:1597373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein N-linked glycosylation via asparagine. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DERL3 (derlin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 31.5), Adrenal (RPKM 25.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Derl3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12753926..12766478, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12754490..12768454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13692102..13707645, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene matrix metallopeptidase 11 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit B1 Neighboring gene uncharacterized LOC134483889 Neighboring gene macrophage migration inhibitory factor Neighboring gene uncharacterized LOC134483888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Belmont PJ, et al. Circ Res, 2010 Feb 5. PMID 19940266, Free PMC Article
    2. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. Oda Y, et al. J Cell Biol, 2006 Jan 30. PMID 16449189, Free PMC Article
    3. Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. Kadowaki H, et al. Cell Rep, 2015 Nov 3. PMID 26565908
    4. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. Sato T, et al. Mol Cell, 2012 Jul 13. PMID 22607976
    5. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study describes a potentially protective role for Derl3 in the heart.
      Title: Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    derlin-3
    Names
    Der1-like domain family, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109577.1 → NP_001103047.2  derlin-3

      Status: PROVISIONAL

      Source sequence(s)
      CH473988
      UniProtKB/TrEMBL
      A6JKF8, B2RZ58, G3V8X2
      Related
      ENSRNOP00000029737.4, ENSRNOT00000038623.7
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 203
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12753926..12766478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099085.2 → XP_038955013.1  derlin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2D0
      Conserved Domains (1) summary
      cl21536
      Location:102 → 226
      Rhomboid; Rhomboid family

    2. XM_063279526.1 → XP_063135596.1  derlin-3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K732, B2RZ58

    3. XM_008773841.4 → XP_008772063.1  derlin-3 isoform X2

      UniProtKB/TrEMBL
      A6JKF8, B2RZ58, G3V8X2
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 203
      DER1; Der1-like family

    4. XM_063279524.1 → XP_063135594.1  derlin-3 isoform X3

      UniProtKB/TrEMBL
      B2RZ58

    5. XM_039099084.2 → XP_038955012.1  derlin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2D0
      Related
      ENSRNOP00000085039.1, ENSRNOT00000116934.2
      Conserved Domains (1) summary
      cl21536
      Location:102 → 226
      Rhomboid; Rhomboid family

    6. XM_063279527.1 → XP_063135597.1  derlin-3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K732, B2RZ58

    7. XM_039099087.2 → XP_038955015.1  derlin-3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K732, B2RZ58

    8. XM_063279523.1 → XP_063135593.1  derlin-3 isoform X2

      UniProtKB/TrEMBL
      A6JKF8, B2RZ58, G3V8X2

    9. XM_039099089.2 → XP_038955017.1  derlin-3 isoform X6

      UniProtKB/TrEMBL
      B2RZ58
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 180
      DER1; Der1-like family

    10. XM_063279525.1 → XP_063135595.1  derlin-3 isoform X3

      UniProtKB/TrEMBL
      B2RZ58

    11. XM_008773842.4 → XP_008772064.1  derlin-3 isoform X3

      UniProtKB/TrEMBL
      B2RZ58
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 202
      DER1; Der1-like family

    12. XM_039099086.2 → XP_038955014.1  derlin-3 isoform X4

      Conserved Domains (1) summary
      cl21536
      Location:65 → 189
      Rhomboid; Rhomboid family

    13. XM_008773839.4 → XP_008772061.1  derlin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2D0
      Conserved Domains (1) summary
      cl21536
      Location:102 → 226
      Rhomboid; Rhomboid family

    14. XM_008773838.4 → XP_008772060.1  derlin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2D0
      Conserved Domains (1) summary
      cl21536
      Location:102 → 226
      Rhomboid; Rhomboid family
    Nucleotide Protein Strain
    Heading Accession and Version

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