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    Isg20 interferon stimulated exonuclease gene 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293052, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Isg20provided by RGD
    Official Full Name
    interferon stimulated exonuclease gene 20provided by RGD
    Primary source
    RGD:1306407
    See related
    EnsemblRapid:ENSRNOG00000054561 AllianceGenome:RGD:1306407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-5' exonuclease activity and RNA binding activity. Predicted to be involved in several processes, including defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be active in nucleus. Orthologous to human ISG20 (interferon stimulated exonuclease gene 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 136.1), Lung (RPKM 85.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Isg20 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (142234729..142246403)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (132829303..132837027)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (140602553..140608892)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099863 Neighboring gene microRNA 8 Neighboring gene apoptosis enhancing nuclease Neighboring gene uncharacterized LOC102547609 Neighboring gene uncharacterized LOC120097803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. Espert L, et al. J Cell Biochem, 2006 Aug 1. PMID 16514659
    2. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. Espert L, et al. J Biol Chem, 2003 May 2. PMID 12594219
    3. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. Nguyen LH, et al. Biochemistry, 2001 Jun 19. PMID 11401564
    4. Molecular cloning of a new interferon-induced PML nuclear body-associated protein. Gongora C, et al. J Biol Chem, 1997 Aug 1. PMID 9235947
    5. Antiviral activities of ISG20 in positive-strand RNA virus infections. Zhou Z, et al. Virology, 2011 Jan 20. PMID 21036379, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105645

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U2 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U3 snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-stimulated gene 20 kDa protein
    Names
    interferon stimulated exonuclease 20
    interferon stimulated gene 20kDa
    interferon-stimulated protein
    NP_001008510.1
    XP_038961563.1
    XP_063140726.1
    XP_063140729.1
    XP_063140731.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008510.1 → NP_001008510.1  interferon-stimulated gene 20 kDa protein

      See identical proteins and their annotated locations for NP_001008510.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086557
      UniProtKB/TrEMBL
      A0A0G2JUC4, A0A8I6AIE3, Q5RJP5
      Related
      ENSRNOP00000075245.3, ENSRNOT00000091588.3
      Conserved Domains (2) summary
      COG0847
      Location:5 → 174
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl10012
      Location:8 → 163
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      142234729..142246403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105635.2 → XP_038961563.1  interferon-stimulated gene 20 kDa protein isoform X1

      Conserved Domains (1) summary
      cl10012
      Location:8 → 159
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    2. XM_063284659.1 → XP_063140729.1  interferon-stimulated gene 20 kDa protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2JUC4, A0A8I6AIE3, Q5RJP5
      Related
      ENSRNOP00000097119.2, ENSRNOT00000097136.2

    3. XM_063284656.1 → XP_063140726.1  interferon-stimulated gene 20 kDa protein isoform X2

    4. XM_063284661.1 → XP_063140731.1  interferon-stimulated gene 20 kDa protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6AIE3
    Nucleotide Protein Strain
    Heading Accession and Version

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