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    Coq10a coenzyme Q10A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362810, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Coq10aprovided by RGD
    Official Full Name
    coenzyme Q10Aprovided by RGD
    Primary source
    RGD:1562447
    See related
    EnsemblRapid:ENSRNOG00000029571 AllianceGenome:RGD:1562447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562447
    Summary
    Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Predicted to be active in mitochondrion. Orthologous to human COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 417.9), Heart (RPKM 194.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coq10a in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1376591..1387694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (792089..798392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2780930..2788189, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 2 Neighboring gene citrate synthase Neighboring gene ankyrin repeat domain 52 Neighboring gene solute carrier family 39 member 5 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene nucleic acid binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulatory effect of exogenous Coenzyme Q(10) on redox and inflammatory biomarkers during aging in rats. Srivastava P, et al. Biol Futur, 2022 Dec. PMID 36443592
    2. Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66(shc)-dependent antioxidant responses. Arany I, et al. Apoptosis, 2017 Feb. PMID 27770269
    3. Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension. Kucharská J, et al. Physiol Res, 2007. PMID 17824807
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulatory effect of exogenous Coenzyme Q10 on redox and inflammatory biomarkers during aging in rats.
      Title: Modulatory effect of exogenous Coenzyme Q(10) on redox and inflammatory biomarkers during aging in rats.
    2. Our studies revealed that Coenzyme Q10 strongly inhibits nicotine-mediated production of reactive oxygen species and consequent apoptosis that requires serine36 phosphorylation but not mitochondrial translocation/cytochrome c binding of p66(shc).
      Title: Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66(shc)-dependent antioxidant responses.
    3. Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle.
      Title: Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coenzyme Q-binding protein COQ10 homolog A, mitochondrial
    Names
    coenzyme Q10 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108727.1 → NP_001102197.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      CH474104
      UniProtKB/TrEMBL
      A6KSC6, D3ZX74
      Related
      ENSRNOP00000044290.3, ENSRNOT00000047530.6
      Conserved Domains (1) summary
      cd07813
      Location:57 → 195
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1376591..1387694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240759.5 → XP_006240821.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6KSC5
      Conserved Domains (1) summary
      cd07813
      Location:89 → 227
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins

    2. XM_039079365.2 → XP_038935293.1  coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYY6
      Related
      ENSRNOP00000070841.2, ENSRNOT00000086939.3
      Conserved Domains (1) summary
      cd07813
      Location:89 → 237
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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