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    Wars1 tryptophanyl-tRNA synthetase1 [ Mus musculus (house mouse) ]

    Gene ID: 22375, updated on 3-Dec-2024

    Summary

    Official Symbol
    Wars1provided by MGI
    Official Full Name
    tryptophanyl-tRNA synthetase1provided by MGI
    Primary source
    MGI:MGI:104630
    See related
    Ensembl:ENSMUSG00000021266 AllianceGenome:MGI:104630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WRS; Wars; TrpRS
    Summary
    Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wars1 in Genome Data Viewer
    Location:
    12 F1; 12 59.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108825956..108860095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108860030..108894175, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tryptophan-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tryptophan-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tryptophanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    Names
    tryptophanyl-tRNA synthetase, cytoplasmic
    NP_001157786.1
    NP_001157960.1
    NP_001398836.1
    NP_001398837.1
    NP_001398838.1
    NP_001398839.1
    NP_035840.3
    XP_006515882.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164314.2NP_001157786.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC122811, AC152061
      Consensus CDS
      CCDS49171.1
      UniProtKB/TrEMBL
      Q3U6U7, Q3UDG2
      Related
      ENSMUSP00000105474.4, ENSMUST00000109848.10
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    2. NM_001164488.2NP_001157960.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001157960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC122811, AC152061
      Consensus CDS
      CCDS49171.1
      UniProtKB/TrEMBL
      Q3U6U7, Q3UDG2
      Related
      ENSMUSP00000125320.2, ENSMUST00000161410.8
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain
    3. NM_001411907.1NP_001398836.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
      Source sequence(s)
      AC122811, AC152061
      UniProtKB/Swiss-Prot
      P32921, Q80ZY4, Q99J58, Q9DC65
      UniProtKB/TrEMBL
      Q4FJZ4
    4. NM_001411908.1NP_001398837.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
      Source sequence(s)
      AC122811, AC152061
      UniProtKB/Swiss-Prot
      P32921, Q80ZY4, Q99J58, Q9DC65
      UniProtKB/TrEMBL
      Q4FJZ4
    5. NM_001411909.1NP_001398838.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
      Source sequence(s)
      AC122811, AC152061
      UniProtKB/Swiss-Prot
      P32921, Q80ZY4, Q99J58, Q9DC65
      UniProtKB/TrEMBL
      Q4FJZ4
    6. NM_001411910.1NP_001398839.1  tryptophan--tRNA ligase, cytoplasmic isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122811, AC152061
      UniProtKB/TrEMBL
      Q4FJZ4
    7. NM_011710.4NP_035840.3  tryptophan--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_035840.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC122811, AC152061
      Consensus CDS
      CCDS26166.1
      UniProtKB/Swiss-Prot
      P32921, Q80ZY4, Q99J58, Q9DC65
      UniProtKB/TrEMBL
      Q4FJZ4
      Related
      ENSMUSP00000124625.2, ENSMUST00000161154.2
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

    RNA

    1. NR_177976.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122811, AC152061
    2. NR_177977.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122811, AC152061

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108825956..108860095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515819.3XP_006515882.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006515882.1

      UniProtKB/Swiss-Prot
      P32921, Q80ZY4, Q99J58, Q9DC65
      UniProtKB/TrEMBL
      Q4FJZ4
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...