U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pacrg PARK2 co-regulated [ Mus musculus (house mouse) ]

    Gene ID: 69310, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pacrgprovided by MGI
    Official Full Name
    PARK2 co-regulatedprovided by MGI
    Primary source
    MGI:MGI:1916560
    See related
    Ensembl:ENSMUSG00000037196 AllianceGenome:MGI:1916560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700008H23Rik
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in flagellated sperm motility. Acts upstream of or within protein localization and spermatid development. Located in several cellular components, including cell body; manchette; and sperm midpiece. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including brain; neural ectoderm; otocyst; pancreas trunk epithelium; and spinal cord ventricular layer. Orthologous to human PACRG (parkin coregulated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 92.0) and frontal lobe adult (RPKM 3.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pacrg in Genome Data Viewer
    Location:
    17 A1; 17 7.8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (10621938..11059078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (10403009..10840191, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700110C19 gene Neighboring gene VISTA enhancer mm1488 Neighboring gene STARR-seq mESC enhancer starr_41803 Neighboring gene STARR-seq mESC enhancer starr_41817 Neighboring gene RIKEN cDNA A230009B12 gene Neighboring gene STARR-seq mESC enhancer starr_41818 Neighboring gene predicted gene, 39565 Neighboring gene STARR-seq mESC enhancer starr_41819 Neighboring gene predicted gene, 52294 Neighboring gene predicted gene, 53987 Neighboring gene STARR-seq mESC enhancer starr_41822 Neighboring gene STARR-seq mESC enhancer starr_41823 Neighboring gene predicted gene 16168 Neighboring gene STARR-seq mESC enhancer starr_41825 Neighboring gene STARR-seq mESC enhancer starr_41826 Neighboring gene STARR-seq mESC enhancer starr_41827 Neighboring gene predicted gene 16169 Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene uncharacterized protein C3orf18 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_41829 Neighboring gene predicted gene, 41526

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    parkin coregulated gene protein homolog
    Names
    PARK2 coregulated gene protein
    hypertension-related protein 1-like protein
    parkin co-regulated gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027032.2NP_081308.1  parkin coregulated gene protein homolog

      See identical proteins and their annotated locations for NP_081308.1

      Status: VALIDATED

      Source sequence(s)
      AK005771, AK135510
      Consensus CDS
      CCDS28388.1
      UniProtKB/Swiss-Prot
      Q7TPF9, Q8CG20, Q9DAK2
      UniProtKB/TrEMBL
      Q0VB91, Q3UXK4
      Related
      ENSMUSP00000044376.7, ENSMUST00000041463.7
      Conserved Domains (2) summary
      pfam10274
      Location:54237
      ParcG; Parkin co-regulated protein
      cl21467
      Location:1954
      Cytochrom_C; Cytochrome c

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      10621938..11059078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523353.4XP_006523416.1  parkin coregulated gene protein homolog isoform X1

      See identical proteins and their annotated locations for XP_006523416.1

      Conserved Domains (1) summary
      pfam10274
      Location:1135
      ParcG; Parkin co-regulated protein