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    Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 57738, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc15a2provided by MGI
    Official Full Name
    solute carrier family 15 (H+/peptide transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1890457
    See related
    Ensembl:ENSMUSG00000022899 AllianceGenome:MGI:1890457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pept2; 8430408C16Rik
    Summary
    Enables dipeptide transmembrane transporter activity and high-affinity oligopeptide transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and regulation of nucleotide-binding activity domain, leucine rich repeat containing receptor signaling pathway. Acts upstream of or within oligopeptide transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 7.8), frontal lobe adult (RPKM 3.5) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc15a2 in Genome Data Viewer
    Location:
    16 B3; 16 25.97 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36570523..36605506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36750161..36785158, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40772 Neighboring gene STARR-positive B cell enhancer mm9_chr16:36711953-36712254 Neighboring gene immunoglobulin-like domain containing receptor 1 Neighboring gene STARR-seq mESC enhancer starr_40773 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40774 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E764 Neighboring gene ELL associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1185 Neighboring gene STARR-positive B cell enhancer ABC_E10903 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5541 Neighboring gene STARR-positive B cell enhancer ABC_E99 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene golgin B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dipeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables high-affinity oligopeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tripeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tripeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dipeptide import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dipeptide import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dipeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dipeptide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oligopeptide transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidoglycan transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tripeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tripeptide import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier family 15 member 2
    Names
    kidney H(+)/peptide cotransporter
    peptide transporter 2
    proton-dependent high affinity oligopeptide transporter PepT2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145899.2NP_001139371.2  solute carrier family 15 member 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment at the 3' end compared to variant 1, which results in a frameshift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117662, AEKQ02018542
      Consensus CDS
      CCDS49842.1
      UniProtKB/TrEMBL
      E9Q329, Q80XC0, Q9CXC0
      Related
      ENSMUSP00000132029.3, ENSMUST00000164579.9
      Conserved Domains (1) summary
      cl28910
      Location:54243
      MFS; Major Facilitator Superfamily
    2. NM_021301.4NP_067276.3  solute carrier family 15 member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC117662, AEKQ02018542
      Consensus CDS
      CCDS28156.1
      UniProtKB/Swiss-Prot
      Q9ES07
      UniProtKB/TrEMBL
      E9QMN8, Q9JM03
      Related
      ENSMUSP00000023616.4, ENSMUST00000023616.11
      Conserved Domains (1) summary
      TIGR00926
      Location:69707
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36570523..36605506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522430.4XP_006522493.1  solute carrier family 15 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006522493.1

      Conserved Domains (1) summary
      TIGR00926
      Location:2403
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RNA

    1. XR_003951808.2 RNA Sequence