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    Wfdc15b WAP four-disulfide core domain 15B [ Mus musculus (house mouse) ]

    Gene ID: 192201, updated on 27-Nov-2024

    Summary

    Official Symbol
    Wfdc15bprovided by MGI
    Official Full Name
    WAP four-disulfide core domain 15Bprovided by MGI
    Primary source
    MGI:MGI:2445041
    See related
    Ensembl:ENSMUSG00000018211 AllianceGenome:MGI:2445041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SWAM1; Wfdc15; 9230106L14Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 137.9), kidney adult (RPKM 134.6) and 2 other tissues See more
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    Genomic context

    See Wfdc15b in Genome Data Viewer
    Location:
    2 H3; 2 84.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164056374..164063583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164214454..164221663, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730032A03 gene Neighboring gene STARR-seq mESC enhancer starr_06321 Neighboring gene WAP four-disulfide core domain 12 Neighboring gene WAP four-disulfide core domain 15A Neighboring gene semenogelin 1 Neighboring gene seminal vesicle secretory protein 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WAP four-disulfide core domain protein 15B
    Names
    WAP four-disulfide core domain 15
    elafin-like protein I
    single WAP motif protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045554.1NP_001039019.1  WAP four-disulfide core domain protein 15B precursor

      Status: VALIDATED

      Source sequence(s)
      BB625483, CB954017
      Consensus CDS
      CCDS38320.1
      UniProtKB/Swiss-Prot
      A2A5M6, Q8BVC0, Q9JHY4
      Related
      ENSMUSP00000018355.5, ENSMUST00000018355.11
      Conserved Domains (1) summary
      pfam00095
      Location:3275
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    2. NM_138685.2NP_619626.1  WAP four-disulfide core domain protein 15B precursor

      Status: VALIDATED

      Source sequence(s)
      BB625483, BC061041, CB954017
      Consensus CDS
      CCDS38320.1
      UniProtKB/Swiss-Prot
      A2A5M6, Q8BVC0, Q9JHY4
      Related
      ENSMUSP00000105001.3, ENSMUST00000109376.9
      Conserved Domains (1) summary
      pfam00095
      Location:3275
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164056374..164063583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498957.3XP_006499020.1  WAP four-disulfide core domain protein 15B isoform X1

      UniProtKB/Swiss-Prot
      A2A5M6, Q8BVC0, Q9JHY4
      Related
      ENSMUSP00000132507.3, ENSMUST00000164567.4
      Conserved Domains (1) summary
      pfam00095
      Location:3275
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'