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    Tomm20 translocase of outer mitochondrial membrane 20 [ Mus musculus (house mouse) ]

    Gene ID: 67952, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tomm20provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 20provided by MGI
    Primary source
    MGI:MGI:1915202
    See related
    Ensembl:ENSMUSG00000093904 AllianceGenome:MGI:1915202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAS20; MOM19; TOM20; Gm19268; mKIAA0016; 1810060K07Rik
    Summary
    Predicted to enable mitochondrion targeting sequence binding activity; protein-transporting ATPase activity; and unfolded protein binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Located in migrasome; mitochondrial envelope; and sperm midpiece. Is active in cell periphery. Is expressed in several structures, including central nervous system; genitourinary system; heart; and liver. Orthologous to human TOMM20 (translocase of outer mitochondrial membrane 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 54.6), placenta adult (RPKM 33.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tomm20 in Genome Data Viewer
    Location:
    8 E2; 8 74.64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (127657414..127672671, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (126930664..126945921, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129281926-129282079 Neighboring gene predicted gene 45805 Neighboring gene STARR-seq mESC enhancer starr_23071 Neighboring gene STARR-seq mESC enhancer starr_23074 Neighboring gene predicted gene, 31718 Neighboring gene VISTA enhancer mm1464 Neighboring gene STARR-positive B cell enhancer ABC_E2883 Neighboring gene STARR-seq mESC enhancer starr_23077 Neighboring gene RIKEN cDNA A630001O12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129371550-129371792 Neighboring gene STARR-positive B cell enhancer ABC_E5051 Neighboring gene STARR-positive B cell enhancer ABC_E6705 Neighboring gene STARR-positive B cell enhancer mm9_chr8:129391519-129391820 Neighboring gene STARR-positive B cell enhancer ABC_E6706 Neighboring gene STARR-positive B cell enhancer ABC_E6707 Neighboring gene predicted gene, 53208 Neighboring gene predicted gene, 26397 Neighboring gene RNA binding motif protein 34 Neighboring gene STARR-seq mESC enhancer starr_23083 Neighboring gene STARR-positive B cell enhancer ABC_E6708 Neighboring gene predicted gene, 29688

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC6333, MGC117642

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitochondrion targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mitochondrion targeting sequence binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitochondrion targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-transporting ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to 3,3',5-triiodo-L-thyronine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in migrasome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitochondrial outer membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitochondrial import receptor subunit TOM20 homolog
    Names
    mitochondrial 20 kDa outer membrane protein
    outer mitochondrial membrane receptor Tom20
    translocase of outer mitochondrial membrane 20 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024214.2NP_077176.1  mitochondrial import receptor subunit TOM20 homolog

      See identical proteins and their annotated locations for NP_077176.1

      Status: VALIDATED

      Source sequence(s)
      AC119874, AK160168, DN174518
      Consensus CDS
      CCDS22786.1
      UniProtKB/Swiss-Prot
      Q9DCC8
      UniProtKB/TrEMBL
      Q4KL41
      Related
      ENSMUSP00000136493.2, ENSMUST00000179857.3
      Conserved Domains (1) summary
      TIGR00985
      Location:1127
      3a0801s04tom; mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      127657414..127672671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)