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    CCR7 C-C motif chemokine receptor 7 [ Homo sapiens (human) ]

    Gene ID: 1236, updated on 4-Jan-2025

    Summary

    Official Symbol
    CCR7provided by HGNC
    Official Full Name
    C-C motif chemokine receptor 7provided by HGNC
    Primary source
    HGNC:HGNC:1608
    See related
    Ensembl:ENSG00000126353 MIM:600242; AllianceGenome:HGNC:1608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7
    Summary
    The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    See CCR7 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40553769..40565472, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41418143..41429846, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38710021..38721724, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371773 Neighboring gene Sharpr-MPRA regulatory region 2600 Neighboring gene uncharacterized LOC107985090 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38716282-38716799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38720363-38721279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12155 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38738644-38738789 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:38744874-38746073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12157 Neighboring gene Sharpr-MPRA regulatory region 2180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12162 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit E1 Neighboring gene Sharpr-MPRA regulatory region 7873 Neighboring gene keratin 222

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCR7 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the level of CXCR4/CCR7 hetero-oligomerization in CD4+ T cells PubMed
    env HIV-1 gp120 interacts with CD4 and CXCR4 to enhance CCR7-dependent human CD4+ T cell migration PubMed
    env Stimulated HIV-1 infected CD4+ cells induce plasmacytoid dendritic cell (PDC) activation and maturation in a manner that is inhibited by antibodies to HIV-1 gp120; markers for PDC migration (CCR7) are enhanced during this process PubMed
    env Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression PubMed
    env HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR7 downregulation in different cell types PubMed
    nef HIV-1 Nef-pulsed mDCs downregulate HLA-DR expression and upregulate CD25 and CCR7 expression in NK cells PubMed
    Vif vif HIV-1 Vif upregulates the expression of chemokine (C-C motif) receptor 7 (CCR7) in Vif-expression T cells PubMed
    Vpu vpu HIV-1 (NL4-3) Vpu downregulates CCR7 expression on cells (primary CD4+ T cells) PubMed
    vpu HIV-1 (NL4-3) Vpu downregulates CCR7 via a cullin-RING E3 ubiquitin ligase complex-independent mechanism PubMed
    vpu HIV-1 Vpu is necessary and sufficient for cell-surface CCR7 downregulation but not degradation of CCR7, and the trans-membrane domain of Vpu is required for downregulation of CCR7 in CD4+ T cells PubMed
    vpu Vpu-mediated downregulation of CCR7 upon viral infection results in an impaired ability of infected primary CD4+ T cells to respond to CCL19 PubMed
    vpu HIV-1 Vpu specifically co-localizes with CCR7 within the trans-Golgi network cellular compartment PubMed
    matrix gag Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 48
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in calcium-mediated signaling  
    involved_in cell chemotaxis  
    involved_in cellular response to cytokine stimulus PubMed 
    involved_in chemokine (C-C motif) ligand 19 signaling pathway  
    involved_in chemokine (C-C motif) ligand 21 signaling pathway  
    involved_in dendritic cell chemotaxis PubMed 
    involved_in establishment of T cell polarity PubMed 
    involved_in homeostasis of number of cells  
    involved_in immune response  
    involved_in inflammatory response PubMed 
    involved_in lymphocyte migration into lymph node PubMed 
    involved_in mature conventional dendritic cell differentiation  
    involved_in myeloid dendritic cell chemotaxis PubMed 
    involved_in myeloid dendritic cell chemotaxis PubMed 
    involved_in negative regulation of dendritic cell apoptotic process PubMed 
    acts_upstream_of negative regulation of interleukin-12 production  
    involved_in negative thymic T cell selection  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of T cell costimulation  
    involved_in positive regulation of T cell receptor signaling pathway  
    involved_in positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell adhesion PubMed 
    involved_in positive regulation of cell motility PubMed 
    involved_in positive regulation of cell-matrix adhesion PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of dendritic cell antigen processing and presentation  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of filopodium assembly PubMed 
    involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation  
    involved_in positive regulation of humoral immune response  
    involved_in positive regulation of hypersensitivity  
    involved_in positive regulation of immunological synapse formation  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of neutrophil chemotaxis PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of pseudopodium assembly PubMed 
    involved_in regulation of dendritic cell dendrite assembly  
    involved_in regulation of interleukin-1 beta production  
    involved_in regulation of type II interferon production  
    involved_in release of sequestered calcium ion into cytosol PubMed 
    involved_in response to lipopolysaccharide  
    involved_in response to nitric oxide PubMed 
    involved_in response to prostaglandin E PubMed 
    involved_in ruffle organization PubMed 
    Items 1 - 25 of 48
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in external side of plasma membrane  
    located_in mitochondrion  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    C-C chemokine receptor type 7
    Names
    Bukitt's lymphoma receptor 2
    CC chemokine receptor 7
    EBV-induced G protein-coupled receptor 1
    Epstein-Barr virus induced gene 1
    Epstein-Barr virus-induced G-protein coupled receptor 1
    MIP-3 beta receptor
    chemokine (C-C motif) receptor 7
    lymphocyte-specific G protein-coupled peptide receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301714.2 → NP_001288643.1  C-C chemokine receptor type 7 isoform b

      See identical proteins and their annotated locations for NP_001288643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      BC035343, BI910219, DA814913
      UniProtKB/TrEMBL
      B2R6V6
      Conserved Domains (1) summary
      pfam00001
      Location:12 → 263
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001301716.2 → NP_001288645.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK310277, BC035343
      Consensus CDS
      CCDS77026.1
      UniProtKB/TrEMBL
      B2R6V6, J3KSS9
      Related
      ENSP00000462631.1, ENST00000579344.2
      Conserved Domains (1) summary
      cd15175
      Location:53 → 331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001301717.2 → NP_001288646.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK310277, BC035343, HY017993
      Consensus CDS
      CCDS77026.1
      UniProtKB/TrEMBL
      B2R6V6, J3KSS9
      Conserved Domains (1) summary
      cd15175
      Location:53 → 331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001301718.2 → NP_001288647.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      BC035343, HY021417
      Consensus CDS
      CCDS77026.1
      UniProtKB/TrEMBL
      B2R6V6, J3KSS9
      Conserved Domains (1) summary
      cd15175
      Location:53 → 331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001838.4 → NP_001829.1  C-C chemokine receptor type 7 isoform a precursor

      See identical proteins and their annotated locations for NP_001829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC035343, L31581
      Consensus CDS
      CCDS11369.1
      UniProtKB/Swiss-Prot
      P32248
      UniProtKB/TrEMBL
      A0N0Q0, B2R6V6
      Related
      ENSP00000246657.2, ENST00000246657.2
      Conserved Domains (1) summary
      cd15175
      Location:59 → 337
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40553769..40565472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41418143..41429846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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