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    AMY2A amylase alpha 2A [ Homo sapiens (human) ]

    Gene ID: 279, updated on 3-Dec-2024

    Summary

    Official Symbol
    AMY2Aprovided by HGNC
    Official Full Name
    amylase alpha 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:477
    See related
    Ensembl:ENSG00000243480 MIM:104650; AllianceGenome:HGNC:477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PA; AMY2
    Summary
    This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]
    Expression
    Restricted expression toward pancreas (RPKM 19140.7) See more
    Orthologs
    NEW
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    Genomic context

    See AMY2A in Genome Data Viewer
    Location:
    1p21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103616651..103625780)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103466373..103474647)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104160049..104168402)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1413 Neighboring gene RNA binding region (RNP1, RRM) containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:104100112-104100330 Neighboring gene amylase alpha 2B Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene uncharacterized LOC124904594 Neighboring gene amylase alpha 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    pancreatic alpha-amylase
    Names
    1,4-alpha-D-glucan glucanohydrolase
    amylase alpha 2A (pancreatic)
    glycogenase
    pancreatic amylase alpha 2A
    NP_000690.1
    XP_047274041.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000699.4NP_000690.1  pancreatic alpha-amylase precursor

      See identical proteins and their annotated locations for NP_000690.1

      Status: REVIEWED

      Source sequence(s)
      AC105272
      Consensus CDS
      CCDS783.1
      UniProtKB/Swiss-Prot
      B9EJG1, P04746
      UniProtKB/TrEMBL
      Q53F26
      Related
      ENSP00000397582.2, ENST00000414303.7
      Conserved Domains (2) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      103616651..103625780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418085.1XP_047274041.1  pancreatic alpha-amylase isoform X1

      UniProtKB/Swiss-Prot
      B9EJG1, P04746
      UniProtKB/TrEMBL
      Q53F26

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      103466373..103474647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)