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    ARHGEF26 Rho guanine nucleotide exchange factor 26 [ Homo sapiens (human) ]

    Gene ID: 26084, updated on 3-Dec-2024

    Summary

    Official Symbol
    ARHGEF26provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 26provided by HGNC
    Primary source
    HGNC:HGNC:24490
    See related
    Ensembl:ENSG00000114790 MIM:617552; AllianceGenome:HGNC:24490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGEF; CSGEF; HMFN1864
    Summary
    This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGEF26 in Genome Data Viewer
    Location:
    3q25.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (154121003..154257825)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (156892016..157032100)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153838792..153975614)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene U8 small nucleolar RNA Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 42 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_65370 Neighboring gene uncharacterized LOC105374167 Neighboring gene MPRA-validated peak4869 silencer Neighboring gene DEAH-box helicase 36 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434D146

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in endothelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 26
    Names
    Rho guanine nucleotide exchange factor (GEF) 26
    SH3 domain-containing guanine exchange factor
    Src homology 3 domain-containing guanine nucleotide exchange factor
    testicular tissue protein Li 171

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030405.1 RefSeqGene

      Range
      5388..141823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251962.2NP_001238891.1  rho guanine nucleotide exchange factor 26 isoform 1

      See identical proteins and their annotated locations for NP_001238891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC018452, AK127282, AY552599
      Consensus CDS
      CCDS46938.1
      UniProtKB/Swiss-Prot
      B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
      UniProtKB/TrEMBL
      A0A140VJU4, B3KXG0
      Related
      ENSP00000348828.4, ENST00000356448.8
      Conserved Domains (3) summary
      cd11938
      Location:793847
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:643781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443622
      RhoGEF; RhoGEF domain
    2. NM_001251963.2NP_001238892.1  rho guanine nucleotide exchange factor 26 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC018452, AK123040, DB069290
      Consensus CDS
      CCDS58858.1
      UniProtKB/TrEMBL
      B3KXG0
      Related
      ENSP00000424446.1, ENST00000496710.5
      Conserved Domains (2) summary
      cd01221
      Location:643781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443622
      RhoGEF; RhoGEF domain
    3. NM_015595.4NP_056410.3  rho guanine nucleotide exchange factor 26 isoform 1

      See identical proteins and their annotated locations for NP_056410.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC018452, AY552599, DA248533, DB069290
      Consensus CDS
      CCDS46938.1
      UniProtKB/Swiss-Prot
      B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
      UniProtKB/TrEMBL
      A0A140VJU4, B3KXG0
      Related
      ENSP00000423418.1, ENST00000465093.6
      Conserved Domains (3) summary
      cd11938
      Location:793847
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:643781
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443622
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      154121003..154257825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512672.2XP_011510974.1  rho guanine nucleotide exchange factor 26 isoform X1

      See identical proteins and their annotated locations for XP_011510974.1

      UniProtKB/TrEMBL
      B3KXG0
      Conserved Domains (3) summary
      cd11938
      Location:763817
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:615751
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:443615
      RhoGEF; RhoGEF domain
    2. XM_047447954.1XP_047303910.1  rho guanine nucleotide exchange factor 26 isoform X2

      UniProtKB/TrEMBL
      B3KXG0

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187533.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      24218..164217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328656.1XP_054184631.1  rho guanine nucleotide exchange factor 26 isoform X2

      UniProtKB/TrEMBL
      B3KXG0
    2. XM_054328655.1XP_054184630.1  rho guanine nucleotide exchange factor 26 isoform X1

      UniProtKB/TrEMBL
      B3KXG0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      156892016..157032100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346146.1XP_054202121.1  rho guanine nucleotide exchange factor 26 isoform X1

      UniProtKB/TrEMBL
      B3KXG0
    2. XM_054346147.1XP_054202122.1  rho guanine nucleotide exchange factor 26 isoform X2

      UniProtKB/TrEMBL
      B3KXG0
    3. XM_054346148.1XP_054202123.1  rho guanine nucleotide exchange factor 26 isoform X3