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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001037335.2 → NP_001032412.2 3'-5' exoribonuclease HELZ2 isoform 1
See identical proteins and their annotated locations for NP_001032412.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AB201715, AK074171, AL121829
- Consensus CDS
-
CCDS33508.1
- UniProtKB/Swiss-Prot
- Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9BYK8, Q9C094
- UniProtKB/TrEMBL
-
A0AAA9XBX5
- Related
- ENSP00000417401.1, ENST00000467148.2
- Conserved Domains (6) summary
-
- cd00009
Location:519 → 590
- AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
- smart00955
Location:1334 → 1693
- RNB; This domain is the catalytic domain of ribonuclease II
- COG1112
Location:642 → 938
- DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
- pfam13086
Location:2152 → 2399
- AAA_11; AAA domain
- pfam13087
Location:2406 → 2611
- AAA_12; AAA domain
- cl22977
Location:715 → 915
- UvrD_C_2; UvrD-like helicase C-terminal domain
-
NM_033405.3 → NP_208384.3 3'-5' exoribonuclease HELZ2 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. It encodes isoform 2, which has a shorter, distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
AK074171, AL121829
- Consensus CDS
-
CCDS13527.1
- UniProtKB/TrEMBL
-
A7E2C9
- Related
- ENSP00000393257.2, ENST00000427522.6
- Conserved Domains (5) summary
-
- smart00955
Location:765 → 1124
- RNB; This domain is the catalytic domain of ribonuclease II
- COG1112
Location:73 → 369
- DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
- pfam13086
Location:1583 → 1830
- AAA_11; AAA domain
- pfam13087
Location:1837 → 2042
- AAA_12; AAA domain
- cl22977
Location:146 → 346
- UvrD_C_2; UvrD-like helicase C-terminal domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000020.11 Reference GRCh38.p14 Primary Assembly
- Range
-
63558086..63574239 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024452006.2 → XP_024307774.1 3'-5' exoribonuclease HELZ2 isoform X1
- UniProtKB/Swiss-Prot
- Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9BYK8, Q9C094
- Conserved Domains (6) summary
-
- smart00451
Location:39 → 69
- ZnF_U1; U1-like zinc finger
- smart00955
Location:1334 → 1693
- RNB; This domain is the catalytic domain of ribonuclease II
- pfam13086
Location:2180 → 2427
- AAA_11; AAA domain
- pfam13087
Location:2434 → 2639
- AAA_12; AAA domain
- cl22977
Location:715 → 915
- UvrD_C_2; UvrD-like helicase C-terminal domain
- cl26261
Location:541 → 705
- AAA_11; AAA domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060944.1 Alternate T2T-CHM13v2.0
- Range
-
65370683..65387688 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054324176.1 → XP_054180151.1 3'-5' exoribonuclease HELZ2 isoform X1
- UniProtKB/Swiss-Prot
- Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9BYK8, Q9C094