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    METTL16 methyltransferase 16, RNA N6-adenosine [ Homo sapiens (human) ]

    Gene ID: 79066, updated on 9-Dec-2024

    Summary

    Official Symbol
    METTL16provided by HGNC
    Official Full Name
    methyltransferase 16, RNA N6-adenosineprovided by HGNC
    Primary source
    HGNC:HGNC:28484
    See related
    Ensembl:ENSG00000127804 AllianceGenome:HGNC:28484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    METT10D
    Summary
    Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA processing and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See METTL16 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2415715..2511888, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2304395..2400696, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2319343..2415182, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2289277-2290101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2291629-2292130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296137-2296704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296705-2297271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2301897-2302468 Neighboring gene hESC enhancers GRCh37_chr17:2302469-2303038 and GRCh37_chr17:2303039-2303609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2305321-2305891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2305892-2306461 Neighboring gene MAX network transcriptional repressor Neighboring gene uncharacterized LOC284009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337127-2337806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337807-2338485 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2338486-2339164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2339165-2339843 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2383040-2383219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2398718-2399218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2403917-2404418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2404419-2404918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2409238-2410149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2410150-2411060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11496 Neighboring gene MPRA-validated peak2683 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2453840-2454586 Neighboring gene RNA, 7SL, cytoplasmic 33, pseudogene Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3329

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA N(6)-adenosine-methyltransferase METTL16; RNA N6-adenosine-methyltransferase METTL16
    Names
    N6-adenosine-methyltransferase METTL16
    N6-methyladenosine methyltransferase
    U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
    U6 snRNA methyltransferase
    methyltransferase 10 domain containing
    methyltransferase 10 domain-containing protein
    methyltransferase 16, N6-methyladenosine
    methyltransferase like 16
    methyltransferase-like protein 16
    putative methyltransferase METT10D
    NP_076991.3
    XP_024306696.1
    XP_047292653.1
    XP_047292654.1
    XP_054173101.1
    XP_054173102.1
    XP_054173103.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024086.4NP_076991.3  RNA N(6)-adenosine-methyltransferase METTL16

      See identical proteins and their annotated locations for NP_076991.3

      Status: VALIDATED

      Source sequence(s)
      AC006435, BC050603, DB227557
      Consensus CDS
      CCDS42232.1
      UniProtKB/Swiss-Prot
      D3DTI8, Q86TE5, Q86W50, Q96T16, Q9BVG7
      Related
      ENSP00000263092.5, ENST00000263092.11
      Conserved Domains (1) summary
      pfam05971
      Location:40291
      Methyltransf_10; Protein of unknown function (DUF890)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      2415715..2511888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436697.1XP_047292653.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

      Related
      ENST00000571669.6
    2. XM_047436698.1XP_047292654.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7
    3. XM_024450928.2XP_024306696.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7
      Conserved Domains (2) summary
      pfam02063
      Location:189284
      MARCKS; MARCKS family
      cl17173
      Location:173
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_007065448.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      2304395..2400696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317126.1XP_054173101.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    2. XM_054317127.1XP_054173102.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7
    3. XM_054317128.1XP_054173103.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7

    RNA

    1. XR_008484933.1 RNA Sequence