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    SPIRE2 spire type actin nucleation factor 2 [ Homo sapiens (human) ]

    Gene ID: 84501, updated on 27-Nov-2024

    Summary

    Official Symbol
    SPIRE2provided by HGNC
    Official Full Name
    spire type actin nucleation factor 2provided by HGNC
    Primary source
    HGNC:HGNC:30623
    See related
    Ensembl:ENSG00000204991 MIM:609217; AllianceGenome:HGNC:30623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Spir-2
    Summary
    Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SPIRE2 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89828475..89871319)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95913065..95956358)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89894883..89937727)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11419 Neighboring gene VPS9D1 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7924 Neighboring gene VPS9 domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89795065-89795636 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46690 Neighboring gene zinc finger protein 276 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46704 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46706 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46707/46708 Neighboring gene MPRA-validated peak2667 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46713 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46714 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46718 Neighboring gene FA complementation group A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11421 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:89846248-89846785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89872952-89873474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7925 Neighboring gene Sharpr-MPRA regulatory region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11422 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7927 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:89900233-89901432 Neighboring gene uncharacterized LOC124903760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89903444-89904066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89904067-89904688 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:89913406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89913685-89914304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89914305-89914923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920364-89920864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920865-89921365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11425 Neighboring gene uncharacterized LOC112268179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89938758-89939714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89945913-89946582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46826 Neighboring gene TCF25 ribosome quality control complex subunit Neighboring gene Sharpr-MPRA regulatory region 15702 Neighboring gene keratin-associated protein 5-1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89978467-89978968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89978969-89979468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89984039-89984924 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:89984925-89985808 and GRCh37_chr16:89985809-89986692 Neighboring gene melanocortin 1 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117166

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cleavage furrow formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formin-nucleated actin cable assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in polar body extrusion after meiotic divisions IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in polar body extrusion after meiotic divisions ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein spire homolog 2
    Names
    spire actin nucleation factor 2
    spire family actin nucleation factor 2
    spire homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032451.2NP_115827.1  protein spire homolog 2

      See identical proteins and their annotated locations for NP_115827.1

      Status: VALIDATED

      Source sequence(s)
      AC092385, AJ422077, AL834408, BC011119, BX439688
      Consensus CDS
      CCDS32516.1
      UniProtKB/Swiss-Prot
      A4QPB1, Q2TA98, Q6P433, Q8ND47, Q8WWL2, Q96JJ5
      Related
      ENSP00000367494.3, ENST00000378247.8
      Conserved Domains (2) summary
      cd15768
      Location:566680
      FYVE_SPIR2; FYVE-related domain found in protein spire homolog 2 (Spire2) and similar proteins
      pfam16474
      Location:22208
      KIND; Kinase non-catalytic C-lobe domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89828475..89871319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95913065..95956358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)