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    SLC18A3 solute carrier family 18 member A3 [ Homo sapiens (human) ]

    Gene ID: 6572, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC18A3provided by HGNC
    Official Full Name
    solute carrier family 18 member A3provided by HGNC
    Primary source
    HGNC:HGNC:10936
    See related
    Ensembl:ENSG00000187714 MIM:600336; AllianceGenome:HGNC:10936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMS21; VACHT
    Summary
    This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See SLC18A3 in Genome Data Viewer
    Location:
    10q11.23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (49610310..49612720)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (50459116..50461526)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50818356..50820766)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 6, chromatin remodeling factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3352 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50745676-50745864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3354 Neighboring gene piggyBac transposable element derived 3 Neighboring gene high mobility group box 1 pseudogene 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50801171-50801672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50801673-50802172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50802781-50803282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50803283-50803782 Neighboring gene Sharpr-MPRA regulatory region 3429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:50816693-50817488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:50817489-50818283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:50819328-50820224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:50820225-50821122 Neighboring gene choline O-acetyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50856078-50856929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50856930-50857780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50858633-50859483 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:50897886-50898488 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:50898489-50899090 Neighboring gene chromosome 10 open reading frame 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50965991-50966502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50966503-50967012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2364 Neighboring gene oxoglutarate dehydrogenase L

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC12716

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylcholine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables acetylcholine:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoamine:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acetylcholine uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter transport TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of acetylcholine secretion, neurotransmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuromuscular junction development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-sculpted acetylcholine transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    vesicular acetylcholine transporter
    Names
    solute carrier family 18 (vesicular acetylcholine transporter), member 3
    solute carrier family 18 (vesicular acetylcholine), member 3
    solute carrier family 18, member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053144.1 RefSeqGene

      Range
      5010..7420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003055.3NP_003046.2  vesicular acetylcholine transporter

      See identical proteins and their annotated locations for NP_003046.2

      Status: REVIEWED

      Source sequence(s)
      AC073366, BC007765, U09210
      Consensus CDS
      CCDS7231.1
      UniProtKB/Swiss-Prot
      B2R7S1, Q16572
      Related
      ENSP00000363229.3, ENST00000374115.5
      Conserved Domains (2) summary
      cd06174
      Location:124458
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:124436
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      49610310..49612720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      50459116..50461526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)