U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FCMR Fc mu receptor [ Homo sapiens (human) ]

    Gene ID: 9214, updated on 9-Dec-2024

    Summary

    Official Symbol
    FCMRprovided by HGNC
    Official Full Name
    Fc mu receptorprovided by HGNC
    Primary source
    HGNC:HGNC:14315
    See related
    Ensembl:ENSG00000162894 MIM:606015; AllianceGenome:HGNC:14315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOSO; FAIM3; FcmuR; IgM FcR
    Summary
    Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
    Expression
    Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCMR in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206903317..206923196, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206167622..206187486, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207076662..207096541, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene interleukin 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene polymeric immunoglobulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgM binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables high-affinity IgM receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polymeric immunoglobulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Fc receptor-mediated immune complex endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in humoral immune response mediated by circulating immunoglobulin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immunoglobulin transcytosis in epithelial cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    immunoglobulin mu Fc receptor
    Names
    Fas apoptotic inhibitory molecule 3
    Fc fragment of IgM receptor
    IgM Fc fragment receptor
    IgM Fc receptor
    regulator of Fas-induced apoptosis Toso

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142473.2NP_001135945.1  immunoglobulin mu Fc receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AA769146, AI524407, BC006401, BP305798, BP338035, CB158779, DA971987
      Consensus CDS
      CCDS44304.1
      UniProtKB/TrEMBL
      B7Z497
      Related
      ENSP00000404136.2, ENST00000442471.4
    2. NM_001193338.2NP_001180267.1  immunoglobulin mu Fc receptor isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935, AI524407, BC006401, HM480394
      Consensus CDS
      CCDS53467.1
      UniProtKB/Swiss-Prot
      O60667
      Related
      ENSP00000485739.1, ENST00000628511.2
      Conserved Domains (2) summary
      cd05716
      Location:24121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25122
      IG_like; Immunoglobulin like
    3. NM_001405862.1NP_001392791.1  immunoglobulin mu Fc receptor isoform d

      Status: VALIDATED

      Source sequence(s)
      AC098935
    4. NM_001405863.1NP_001392792.1  immunoglobulin mu Fc receptor isoform d

      Status: VALIDATED

      Source sequence(s)
      AC098935
    5. NM_001405864.1NP_001392793.1  immunoglobulin mu Fc receptor isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    6. NM_001405865.1NP_001392794.1  immunoglobulin mu Fc receptor isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    7. NM_001405866.1NP_001392795.1  immunoglobulin mu Fc receptor isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    8. NM_001405867.1NP_001392796.1  immunoglobulin mu Fc receptor isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    9. NM_001405868.1NP_001392797.1  immunoglobulin mu Fc receptor isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    10. NM_001405871.1NP_001392800.1  immunoglobulin mu Fc receptor isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
      UniProtKB/Swiss-Prot
      A8K7J2, B7Z6Z0, D9MWM3, O60667
    11. NM_001405886.1NP_001392815.1  immunoglobulin mu Fc receptor isoform h

      Status: VALIDATED

      Source sequence(s)
      AC098935
      UniProtKB/TrEMBL
      B7Z497
    12. NM_001405887.1NP_001392816.1  immunoglobulin mu Fc receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AC098935
      UniProtKB/TrEMBL
      B7Z497
    13. NM_001405888.1NP_001392817.1  immunoglobulin mu Fc receptor isoform j

      Status: VALIDATED

      Source sequence(s)
      AC098935
    14. NM_001405889.1NP_001392818.1  immunoglobulin mu Fc receptor isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    15. NM_001405890.1NP_001392819.1  immunoglobulin mu Fc receptor isoform l

      Status: VALIDATED

      Source sequence(s)
      AC098935
    16. NM_001405891.1NP_001392820.1  immunoglobulin mu Fc receptor isoform m

      Status: VALIDATED

      Source sequence(s)
      AC098935
    17. NM_001405892.1NP_001392821.1  immunoglobulin mu Fc receptor isoform n precursor

      Status: VALIDATED

      Source sequence(s)
      AC098935
    18. NM_005449.5NP_005440.1  immunoglobulin mu Fc receptor isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AA769146, AI524407, BC006401, BP338035, CB158779
      Consensus CDS
      CCDS1473.1
      UniProtKB/Swiss-Prot
      A8K7J2, B7Z6Z0, D9MWM3, O60667
      Related
      ENSP00000356058.3, ENST00000367091.8
      Conserved Domains (2) summary
      cd05716
      Location:24121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25122
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206903317..206923196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434331.1XP_047290287.1  immunoglobulin mu Fc receptor isoform X1

      UniProtKB/TrEMBL
      B7Z497
    2. XM_047434334.1XP_047290290.1  immunoglobulin mu Fc receptor isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206167622..206187486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339614.1XP_054195589.1  immunoglobulin mu Fc receptor isoform X1

      UniProtKB/TrEMBL
      B7Z497
    2. XM_054339615.1XP_054195590.1  immunoglobulin mu Fc receptor isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001142472.1: Suppressed sequence

      Description
      NM_001142472.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.