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    DDX60 DExD/H-box helicase 60 [ Homo sapiens (human) ]

    Gene ID: 55601, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DDX60provided by HGNC
    Official Full Name
    DExD/H-box helicase 60provided by HGNC
    Primary source
    HGNC:HGNC:25942
    See related
    Ensembl:ENSG00000137628 MIM:613974; AllianceGenome:HGNC:25942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in stomach (RPKM 14.0), colon (RPKM 7.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See DDX60 in Genome Data Viewer
    Location:
    4q32.3
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (168216294..168325979, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (171575326..171684983, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169137445..169239903, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900170 Neighboring gene annexin A10 Neighboring gene uncharacterized LOC105377524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22124 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76110 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76114 Neighboring gene DExD/H-box 60 like Neighboring gene small nucleolar RNA SNORA51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22125 Neighboring gene uncharacterized LOC107986198 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:169408038-169409237 Neighboring gene palladin, cytoskeletal associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DDX60 Promotes Migration and Invasion of Head and Neck Squamous Cell Carcinoma Cell through the NF-κB/IFI27 Signaling Pathway. Han Y, et al. Front Biosci (Landmark Ed), 2024 Jan 17. PMID 38287816
    2. Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling. Nakamura Y, et al. Mol Biol Rep, 2024 Jan 18. PMID 38236450
    3. Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma. Fu TY, et al. Oncotarget, 2016 Dec 20. PMID 27835882, Free PMC Article
    4. Integrative Bioinformatics Analysis Identifies DDX60 as a Potential Biomarker for Systemic Lupus Erythematosus. Chen W, et al. Dis Markers, 2023. PMID 36655136, Free PMC Article
    5. Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry. Zhou Y, et al. Sci Immunol, 2024 Oct 4. PMID 39365875

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry.
      Title: Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry.
    2. DDX60 Promotes Migration and Invasion of Head and Neck Squamous Cell Carcinoma Cell through the NF-kappaB/IFI27 Signaling Pathway.
      Title: DDX60 Promotes Migration and Invasion of Head and Neck Squamous Cell Carcinoma Cell through the NF-κB/IFI27 Signaling Pathway.
    3. Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling.
      Title: Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling.
    4. Integrative Bioinformatics Analysis Identifies DDX60 as a Potential Biomarker for Systemic Lupus Erythematosus.
      Title: Integrative Bioinformatics Analysis Identifies DDX60 as a Potential Biomarker for Systemic Lupus Erythematosus.
    5. Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis.
      Title: Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis.
    6. DDX60 is a novel and unfavorable biomarker for tumorigenesis and prognosis of oral squamous cell carcinoma in a subsite-specific manner
      Title: Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
    7. Results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation.
      Title: DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
    8. DDX60 is a novel antiviral helicase promoting RIG-I-like receptor-mediated signaling.
      Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of DDX60 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10787, FLJ20035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MDA-5 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX60
    Names
    ATP-dependent RNA helicase DDX60
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
    DEAD box protein 60
    DEAD-box helicase 60
    NP_001397790.1
    NP_060101.3
    XP_011530406.1
    XP_016863872.1
    XP_016863873.1
    XP_024309900.1
    XP_024309901.1
    XP_054206430.1
    XP_054206431.1
    XP_054206432.1
    XP_054206433.1
    XP_054206434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054636.2 RefSeqGene

      Range
      12227..114685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001410861.1 → NP_001397790.1  probable ATP-dependent RNA helicase DDX60 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC068989, AC093888
      Consensus CDS
      CCDS93666.1
      UniProtKB/TrEMBL
      A0A7P0T8Y0, A0A7P0TAZ7
      Related
      ENSP00000505292.1, ENST00000680771.1

    2. NM_017631.6 → NP_060101.3  probable ATP-dependent RNA helicase DDX60 isoform 1

      See identical proteins and their annotated locations for NP_060101.3

      Status: REVIEWED

      Source sequence(s)
      AK001649, AK307404, BC020601, BC038115, BC074781
      Consensus CDS
      CCDS34097.1
      UniProtKB/Swiss-Prot
      Q6PK35, Q8IY21, Q9NVE3
      UniProtKB/TrEMBL
      A0A3G9HN97, A0A7P0TAZ7
      Related
      ENSP00000377344.3, ENST00000393743.8
      Conserved Domains (1) summary
      cl28230
      Location:762 → 1373
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      168216294..168325979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454132.2 → XP_024309900.1  probable ATP-dependent RNA helicase DDX60 isoform X1

      UniProtKB/Swiss-Prot
      Q6PK35, Q8IY21, Q9NVE3
      UniProtKB/TrEMBL
      A0A3G9HN97, A0A7P0TAZ7
      Conserved Domains (1) summary
      cl28230
      Location:762 → 1373
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

    2. XM_024454133.2 → XP_024309901.1  probable ATP-dependent RNA helicase DDX60 isoform X1

      UniProtKB/Swiss-Prot
      Q6PK35, Q8IY21, Q9NVE3
      UniProtKB/TrEMBL
      A0A3G9HN97, A0A7P0TAZ7
      Conserved Domains (1) summary
      cl28230
      Location:762 → 1373
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

    3. XM_011532104.4 → XP_011530406.1  probable ATP-dependent RNA helicase DDX60 isoform X2

      UniProtKB/TrEMBL
      A0A7P0TAZ7
      Conserved Domains (1) summary
      pfam00270
      Location:768 → 922
      DEAD; DEAD/DEAH box helicase

    4. XM_017008384.2 → XP_016863873.1  probable ATP-dependent RNA helicase DDX60 isoform X4

    5. XM_017008383.2 → XP_016863872.1  probable ATP-dependent RNA helicase DDX60 isoform X3

      Related
      ENST00000679744.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      171575326..171684983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350456.1 → XP_054206431.1  probable ATP-dependent RNA helicase DDX60 isoform X1

      UniProtKB/Swiss-Prot
      Q6PK35, Q8IY21, Q9NVE3
      UniProtKB/TrEMBL
      A0A3G9HN97, A0A7P0TAZ7

    2. XM_054350455.1 → XP_054206430.1  probable ATP-dependent RNA helicase DDX60 isoform X1

      UniProtKB/Swiss-Prot
      Q6PK35, Q8IY21, Q9NVE3
      UniProtKB/TrEMBL
      A0A3G9HN97, A0A7P0TAZ7

    3. XM_054350457.1 → XP_054206432.1  probable ATP-dependent RNA helicase DDX60 isoform X2

      UniProtKB/TrEMBL
      A0A7P0TAZ7

    4. XM_054350459.1 → XP_054206434.1  probable ATP-dependent RNA helicase DDX60 isoform X4

    5. XM_054350458.1 → XP_054206433.1  probable ATP-dependent RNA helicase DDX60 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IY21.3 GenPept UniProtKB/Swiss-Prot:Q8IY21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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